HECT domain interaction with ubiquitin binding sites on Tsg101-UEV controls HIV-1 egress, maturation, and infectivity

The HECT domain of HECT E3 ligases consists of flexibly linked N- and C-terminal lobes, with a ubiquitin (Ub) donor site on the C-lobe that is directly involved in substrate modification. HECT ligases also possess a secondary Ub binding site in the N-lobe, which is thought to play a role in processi...

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Detalles Bibliográficos
Autores principales: Nyenhuis, David A., Rajasekaran, Rohith, Watanabe, Susan, Strub, Marie-Paule, Khan, Mahfuz, Powell, Michael, Carter, Carol A., Tjandra, Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944984/
https://www.ncbi.nlm.nih.gov/pubmed/36642186
http://dx.doi.org/10.1016/j.jbc.2023.102901

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