Cargando…

A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration

The incorporation of bioactive and biocompatible fillers improve the bone cell adhesion, proliferation and differentiation, thus facilitating new bone tissue formation upon implantation. During these last 20 years, those biocomposites have been explored for making complex geometry devices likes scre...

Descripción completa

Detalles Bibliográficos
Autores principales: Lacambra-Andreu, Xavier, Maazouz, Abderrahim, Lamnawar, Khalid, Chenal, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945144/
https://www.ncbi.nlm.nih.gov/pubmed/36810412
http://dx.doi.org/10.3390/biomimetics8010081
_version_ 1784892076866928640
author Lacambra-Andreu, Xavier
Maazouz, Abderrahim
Lamnawar, Khalid
Chenal, Jean-Marc
author_facet Lacambra-Andreu, Xavier
Maazouz, Abderrahim
Lamnawar, Khalid
Chenal, Jean-Marc
author_sort Lacambra-Andreu, Xavier
collection PubMed
description The incorporation of bioactive and biocompatible fillers improve the bone cell adhesion, proliferation and differentiation, thus facilitating new bone tissue formation upon implantation. During these last 20 years, those biocomposites have been explored for making complex geometry devices likes screws or 3D porous scaffolds for the repair of bone defects. This review provides an overview of the current development of manufacturing process with synthetic biodegradable poly(α-ester)s reinforced with bioactive fillers for bone tissue engineering applications. Firstly, the properties of poly(α-ester), bioactive fillers, as well as their composites will be defined. Then, the different works based on these biocomposites will be classified according to their manufacturing process. New processing techniques, particularly additive manufacturing processes, open up a new range of possibilities. These techniques have shown the possibility to customize bone implants for each patient and even create scaffolds with a complex structure similar to bone. At the end of this manuscript, a contextualization exercise will be performed to identify the main issues of process/resorbable biocomposites combination identified in the literature and especially for resorbable load-bearing applications.
format Online
Article
Text
id pubmed-9945144
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99451442023-02-23 A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration Lacambra-Andreu, Xavier Maazouz, Abderrahim Lamnawar, Khalid Chenal, Jean-Marc Biomimetics (Basel) Review The incorporation of bioactive and biocompatible fillers improve the bone cell adhesion, proliferation and differentiation, thus facilitating new bone tissue formation upon implantation. During these last 20 years, those biocomposites have been explored for making complex geometry devices likes screws or 3D porous scaffolds for the repair of bone defects. This review provides an overview of the current development of manufacturing process with synthetic biodegradable poly(α-ester)s reinforced with bioactive fillers for bone tissue engineering applications. Firstly, the properties of poly(α-ester), bioactive fillers, as well as their composites will be defined. Then, the different works based on these biocomposites will be classified according to their manufacturing process. New processing techniques, particularly additive manufacturing processes, open up a new range of possibilities. These techniques have shown the possibility to customize bone implants for each patient and even create scaffolds with a complex structure similar to bone. At the end of this manuscript, a contextualization exercise will be performed to identify the main issues of process/resorbable biocomposites combination identified in the literature and especially for resorbable load-bearing applications. MDPI 2023-02-14 /pmc/articles/PMC9945144/ /pubmed/36810412 http://dx.doi.org/10.3390/biomimetics8010081 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lacambra-Andreu, Xavier
Maazouz, Abderrahim
Lamnawar, Khalid
Chenal, Jean-Marc
A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration
title A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration
title_full A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration
title_fullStr A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration
title_full_unstemmed A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration
title_short A Review on Manufacturing Processes of Biocomposites Based on Poly(α-Esters) and Bioactive Glass Fillers for Bone Regeneration
title_sort review on manufacturing processes of biocomposites based on poly(α-esters) and bioactive glass fillers for bone regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945144/
https://www.ncbi.nlm.nih.gov/pubmed/36810412
http://dx.doi.org/10.3390/biomimetics8010081
work_keys_str_mv AT lacambraandreuxavier areviewonmanufacturingprocessesofbiocompositesbasedonpolyaestersandbioactiveglassfillersforboneregeneration
AT maazouzabderrahim areviewonmanufacturingprocessesofbiocompositesbasedonpolyaestersandbioactiveglassfillersforboneregeneration
AT lamnawarkhalid areviewonmanufacturingprocessesofbiocompositesbasedonpolyaestersandbioactiveglassfillersforboneregeneration
AT chenaljeanmarc areviewonmanufacturingprocessesofbiocompositesbasedonpolyaestersandbioactiveglassfillersforboneregeneration
AT lacambraandreuxavier reviewonmanufacturingprocessesofbiocompositesbasedonpolyaestersandbioactiveglassfillersforboneregeneration
AT maazouzabderrahim reviewonmanufacturingprocessesofbiocompositesbasedonpolyaestersandbioactiveglassfillersforboneregeneration
AT lamnawarkhalid reviewonmanufacturingprocessesofbiocompositesbasedonpolyaestersandbioactiveglassfillersforboneregeneration
AT chenaljeanmarc reviewonmanufacturingprocessesofbiocompositesbasedonpolyaestersandbioactiveglassfillersforboneregeneration