Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21(low) B cells in hepatitis C virus-cured mixed cryoglobulinemia

INTRODUCTION: Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of B cells expressing B cell receptors (BCRs), often encoded by the VH1-69 variable gene, endowed with both rheumatoid factor (RF) and anti-HCV specificity. These cells display an atypical CD21low ph...

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Detalles Bibliográficos
Autores principales: Del Padre, Martina, Marrapodi, Ramona, Minafò, Ylenia A., Piano Mortari, Eva, Radicchio, Giovanna, Bocci, Chiara, Gragnani, Laura, Camponeschi, Alessandro, Colantuono, Stefania, Stefanini, Lucia, Basili, Stefania, Carsetti, Rita, Fiorilli, Massimo, Casato, Milvia, Visentini, Marcella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945227/
https://www.ncbi.nlm.nih.gov/pubmed/36845129
http://dx.doi.org/10.3389/fimmu.2023.1094871

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