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Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study

OBJECTIVE: The study aimed to evaluate the non-cancer-specific death risk and identify the risk factors affecting the non-cancer-specific survival (NCSS) in patients with primary central nervous system lymphoma (PCNSL). METHODS: This multi-center cohort study included 2497 patients with PCNSL in the...

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Autores principales: Chi, Kaiyi, Zhou, Ruoyun, Luo, Zehao, Zhao, Hongjun, Jiang, Yanting, He, Baixin, Li, Yemin, Chen, Dongting, Feng, Manting, Liang, Yinglan, Yang, Wenting, Liu, Ruisi, Yao, Dunchen, Lin, Xiaozhen, Xu, Xiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945279/
https://www.ncbi.nlm.nih.gov/pubmed/36845683
http://dx.doi.org/10.3389/fonc.2023.1096027
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author Chi, Kaiyi
Zhou, Ruoyun
Luo, Zehao
Zhao, Hongjun
Jiang, Yanting
He, Baixin
Li, Yemin
Chen, Dongting
Feng, Manting
Liang, Yinglan
Yang, Wenting
Liu, Ruisi
Yao, Dunchen
Lin, Xiaozhen
Xu, Xiuhong
author_facet Chi, Kaiyi
Zhou, Ruoyun
Luo, Zehao
Zhao, Hongjun
Jiang, Yanting
He, Baixin
Li, Yemin
Chen, Dongting
Feng, Manting
Liang, Yinglan
Yang, Wenting
Liu, Ruisi
Yao, Dunchen
Lin, Xiaozhen
Xu, Xiuhong
author_sort Chi, Kaiyi
collection PubMed
description OBJECTIVE: The study aimed to evaluate the non-cancer-specific death risk and identify the risk factors affecting the non-cancer-specific survival (NCSS) in patients with primary central nervous system lymphoma (PCNSL). METHODS: This multi-center cohort study included 2497 patients with PCNSL in the Surveillance, Epidemiology and End Results (SEER) database from 2007 to 2016, with a mean follow-up of 4.54 years. The non-cancer-specific death risk in patients with PCNSL and primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) was evaluated using the proportion of deaths, standardized mortality ratio (SMR), and absolute excess risk (AER). Univariate and multivariate competing risk regression models were utilized to identify the risk factors of NCSS. RESULTS: PCNSL was the most frequent cause of death in PCNSL patients (75.03%). Non-cancer-specific causes constituted a non-negligible portion of death (20.61%). Compared with the general population, PCNSL patients had higher risks of death from cardiovascular disease (CVD) (SMR, 2.55; AER, 77.29), Alzheimer’s disease (SMR, 2.71; AER, 8.79), respiratory disease (SMR, 2.12; AER, 15.63), and other non-cancer-specific diseases (SMR, 4.12; AER, 83.12). Male sex, Black race, earlier year of diagnosis (2007–2011), being unmarried, and a lack of chemotherapy were risk factors for NCSS in patients with PCNSL and PCNS-DLBCL (all P < 0.05). CONCLUSION: Non-cancer-specific causes were important competing causes of death in PCNSL patients. More attention is recommended to non-cancer-specific causes of death in the management of PCNSL patients.
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spelling pubmed-99452792023-02-23 Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study Chi, Kaiyi Zhou, Ruoyun Luo, Zehao Zhao, Hongjun Jiang, Yanting He, Baixin Li, Yemin Chen, Dongting Feng, Manting Liang, Yinglan Yang, Wenting Liu, Ruisi Yao, Dunchen Lin, Xiaozhen Xu, Xiuhong Front Oncol Oncology OBJECTIVE: The study aimed to evaluate the non-cancer-specific death risk and identify the risk factors affecting the non-cancer-specific survival (NCSS) in patients with primary central nervous system lymphoma (PCNSL). METHODS: This multi-center cohort study included 2497 patients with PCNSL in the Surveillance, Epidemiology and End Results (SEER) database from 2007 to 2016, with a mean follow-up of 4.54 years. The non-cancer-specific death risk in patients with PCNSL and primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) was evaluated using the proportion of deaths, standardized mortality ratio (SMR), and absolute excess risk (AER). Univariate and multivariate competing risk regression models were utilized to identify the risk factors of NCSS. RESULTS: PCNSL was the most frequent cause of death in PCNSL patients (75.03%). Non-cancer-specific causes constituted a non-negligible portion of death (20.61%). Compared with the general population, PCNSL patients had higher risks of death from cardiovascular disease (CVD) (SMR, 2.55; AER, 77.29), Alzheimer’s disease (SMR, 2.71; AER, 8.79), respiratory disease (SMR, 2.12; AER, 15.63), and other non-cancer-specific diseases (SMR, 4.12; AER, 83.12). Male sex, Black race, earlier year of diagnosis (2007–2011), being unmarried, and a lack of chemotherapy were risk factors for NCSS in patients with PCNSL and PCNS-DLBCL (all P < 0.05). CONCLUSION: Non-cancer-specific causes were important competing causes of death in PCNSL patients. More attention is recommended to non-cancer-specific causes of death in the management of PCNSL patients. Frontiers Media S.A. 2023-02-08 /pmc/articles/PMC9945279/ /pubmed/36845683 http://dx.doi.org/10.3389/fonc.2023.1096027 Text en Copyright © 2023 Chi, Zhou, Luo, Zhao, Jiang, He, Li, Chen, Feng, Liang, Yang, Liu, Yao, Lin and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chi, Kaiyi
Zhou, Ruoyun
Luo, Zehao
Zhao, Hongjun
Jiang, Yanting
He, Baixin
Li, Yemin
Chen, Dongting
Feng, Manting
Liang, Yinglan
Yang, Wenting
Liu, Ruisi
Yao, Dunchen
Lin, Xiaozhen
Xu, Xiuhong
Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study
title Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study
title_full Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study
title_fullStr Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study
title_full_unstemmed Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study
title_short Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study
title_sort non-cancer-specific survival in patients with primary central nervous system lymphoma: a multi-center cohort study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945279/
https://www.ncbi.nlm.nih.gov/pubmed/36845683
http://dx.doi.org/10.3389/fonc.2023.1096027
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