Cargando…
Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study
OBJECTIVE: The study aimed to evaluate the non-cancer-specific death risk and identify the risk factors affecting the non-cancer-specific survival (NCSS) in patients with primary central nervous system lymphoma (PCNSL). METHODS: This multi-center cohort study included 2497 patients with PCNSL in the...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945279/ https://www.ncbi.nlm.nih.gov/pubmed/36845683 http://dx.doi.org/10.3389/fonc.2023.1096027 |
_version_ | 1784892106437820416 |
---|---|
author | Chi, Kaiyi Zhou, Ruoyun Luo, Zehao Zhao, Hongjun Jiang, Yanting He, Baixin Li, Yemin Chen, Dongting Feng, Manting Liang, Yinglan Yang, Wenting Liu, Ruisi Yao, Dunchen Lin, Xiaozhen Xu, Xiuhong |
author_facet | Chi, Kaiyi Zhou, Ruoyun Luo, Zehao Zhao, Hongjun Jiang, Yanting He, Baixin Li, Yemin Chen, Dongting Feng, Manting Liang, Yinglan Yang, Wenting Liu, Ruisi Yao, Dunchen Lin, Xiaozhen Xu, Xiuhong |
author_sort | Chi, Kaiyi |
collection | PubMed |
description | OBJECTIVE: The study aimed to evaluate the non-cancer-specific death risk and identify the risk factors affecting the non-cancer-specific survival (NCSS) in patients with primary central nervous system lymphoma (PCNSL). METHODS: This multi-center cohort study included 2497 patients with PCNSL in the Surveillance, Epidemiology and End Results (SEER) database from 2007 to 2016, with a mean follow-up of 4.54 years. The non-cancer-specific death risk in patients with PCNSL and primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) was evaluated using the proportion of deaths, standardized mortality ratio (SMR), and absolute excess risk (AER). Univariate and multivariate competing risk regression models were utilized to identify the risk factors of NCSS. RESULTS: PCNSL was the most frequent cause of death in PCNSL patients (75.03%). Non-cancer-specific causes constituted a non-negligible portion of death (20.61%). Compared with the general population, PCNSL patients had higher risks of death from cardiovascular disease (CVD) (SMR, 2.55; AER, 77.29), Alzheimer’s disease (SMR, 2.71; AER, 8.79), respiratory disease (SMR, 2.12; AER, 15.63), and other non-cancer-specific diseases (SMR, 4.12; AER, 83.12). Male sex, Black race, earlier year of diagnosis (2007–2011), being unmarried, and a lack of chemotherapy were risk factors for NCSS in patients with PCNSL and PCNS-DLBCL (all P < 0.05). CONCLUSION: Non-cancer-specific causes were important competing causes of death in PCNSL patients. More attention is recommended to non-cancer-specific causes of death in the management of PCNSL patients. |
format | Online Article Text |
id | pubmed-9945279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99452792023-02-23 Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study Chi, Kaiyi Zhou, Ruoyun Luo, Zehao Zhao, Hongjun Jiang, Yanting He, Baixin Li, Yemin Chen, Dongting Feng, Manting Liang, Yinglan Yang, Wenting Liu, Ruisi Yao, Dunchen Lin, Xiaozhen Xu, Xiuhong Front Oncol Oncology OBJECTIVE: The study aimed to evaluate the non-cancer-specific death risk and identify the risk factors affecting the non-cancer-specific survival (NCSS) in patients with primary central nervous system lymphoma (PCNSL). METHODS: This multi-center cohort study included 2497 patients with PCNSL in the Surveillance, Epidemiology and End Results (SEER) database from 2007 to 2016, with a mean follow-up of 4.54 years. The non-cancer-specific death risk in patients with PCNSL and primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) was evaluated using the proportion of deaths, standardized mortality ratio (SMR), and absolute excess risk (AER). Univariate and multivariate competing risk regression models were utilized to identify the risk factors of NCSS. RESULTS: PCNSL was the most frequent cause of death in PCNSL patients (75.03%). Non-cancer-specific causes constituted a non-negligible portion of death (20.61%). Compared with the general population, PCNSL patients had higher risks of death from cardiovascular disease (CVD) (SMR, 2.55; AER, 77.29), Alzheimer’s disease (SMR, 2.71; AER, 8.79), respiratory disease (SMR, 2.12; AER, 15.63), and other non-cancer-specific diseases (SMR, 4.12; AER, 83.12). Male sex, Black race, earlier year of diagnosis (2007–2011), being unmarried, and a lack of chemotherapy were risk factors for NCSS in patients with PCNSL and PCNS-DLBCL (all P < 0.05). CONCLUSION: Non-cancer-specific causes were important competing causes of death in PCNSL patients. More attention is recommended to non-cancer-specific causes of death in the management of PCNSL patients. Frontiers Media S.A. 2023-02-08 /pmc/articles/PMC9945279/ /pubmed/36845683 http://dx.doi.org/10.3389/fonc.2023.1096027 Text en Copyright © 2023 Chi, Zhou, Luo, Zhao, Jiang, He, Li, Chen, Feng, Liang, Yang, Liu, Yao, Lin and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Chi, Kaiyi Zhou, Ruoyun Luo, Zehao Zhao, Hongjun Jiang, Yanting He, Baixin Li, Yemin Chen, Dongting Feng, Manting Liang, Yinglan Yang, Wenting Liu, Ruisi Yao, Dunchen Lin, Xiaozhen Xu, Xiuhong Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study |
title | Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study |
title_full | Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study |
title_fullStr | Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study |
title_full_unstemmed | Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study |
title_short | Non-cancer-specific survival in patients with primary central nervous system lymphoma: A multi-center cohort study |
title_sort | non-cancer-specific survival in patients with primary central nervous system lymphoma: a multi-center cohort study |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945279/ https://www.ncbi.nlm.nih.gov/pubmed/36845683 http://dx.doi.org/10.3389/fonc.2023.1096027 |
work_keys_str_mv | AT chikaiyi noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT zhouruoyun noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT luozehao noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT zhaohongjun noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT jiangyanting noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT hebaixin noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT liyemin noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT chendongting noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT fengmanting noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT liangyinglan noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT yangwenting noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT liuruisi noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT yaodunchen noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT linxiaozhen noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy AT xuxiuhong noncancerspecificsurvivalinpatientswithprimarycentralnervoussystemlymphomaamulticentercohortstudy |