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Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism

INTRODUCTION: To explore the association between regional gray matter volume (GMV) and cognitive impairments and ascertain whether the regional brain alterations related to cognitive impairments occur in major depressive disorder (MDD) patients with comorbid subclinical hypothyroidism (SHypo). METHO...

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Autores principales: Zhao, Shuai, Du, Yishan, Zhang, Yu, Wang, Xiaoqin, Xia, Yi, Sun, Hao, Huang, Yinghong, Zou, Haowen, Wang, Xumiao, Chen, Zhilu, Zhou, Hongliang, Yan, Rui, Tang, Hao, Lu, Qing, Yao, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945283/
https://www.ncbi.nlm.nih.gov/pubmed/36845662
http://dx.doi.org/10.3389/fnagi.2023.1106792
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author Zhao, Shuai
Du, Yishan
Zhang, Yu
Wang, Xiaoqin
Xia, Yi
Sun, Hao
Huang, Yinghong
Zou, Haowen
Wang, Xumiao
Chen, Zhilu
Zhou, Hongliang
Yan, Rui
Tang, Hao
Lu, Qing
Yao, Zhijian
author_facet Zhao, Shuai
Du, Yishan
Zhang, Yu
Wang, Xiaoqin
Xia, Yi
Sun, Hao
Huang, Yinghong
Zou, Haowen
Wang, Xumiao
Chen, Zhilu
Zhou, Hongliang
Yan, Rui
Tang, Hao
Lu, Qing
Yao, Zhijian
author_sort Zhao, Shuai
collection PubMed
description INTRODUCTION: To explore the association between regional gray matter volume (GMV) and cognitive impairments and ascertain whether the regional brain alterations related to cognitive impairments occur in major depressive disorder (MDD) patients with comorbid subclinical hypothyroidism (SHypo). METHODS: We enrolled 32 MDD patients, 32 MDD patients with comorbid SHypo, and 32 normal controls and subjected them to thyroid function tests, neurocognitive tests, and magnetic resonance imaging (MRI). Using voxel-based morphometry (VBM) analysis, we examined the pattern of gray matter (GM) in these participants. We also used ANOVA to detect group differences and partial correlation to explore the potential association between GMV alterations and cognitive tests in comorbid patients. RESULTS: The comorbid patients exhibited significantly smaller GMV in the right middle frontal gyrus (MFG) than the non-comorbid group. Furthermore, the partial correlation analysis showed that GMV of the right MFG was associated with poor executive function (EF) performance in comorbid patients. CONCLUSION: These findings provide valuable insight into the relationship between the alteration of GMV and cognitive dysfunction of MDD patients with comorbid SHypo.
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spelling pubmed-99452832023-02-23 Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism Zhao, Shuai Du, Yishan Zhang, Yu Wang, Xiaoqin Xia, Yi Sun, Hao Huang, Yinghong Zou, Haowen Wang, Xumiao Chen, Zhilu Zhou, Hongliang Yan, Rui Tang, Hao Lu, Qing Yao, Zhijian Front Aging Neurosci Aging Neuroscience INTRODUCTION: To explore the association between regional gray matter volume (GMV) and cognitive impairments and ascertain whether the regional brain alterations related to cognitive impairments occur in major depressive disorder (MDD) patients with comorbid subclinical hypothyroidism (SHypo). METHODS: We enrolled 32 MDD patients, 32 MDD patients with comorbid SHypo, and 32 normal controls and subjected them to thyroid function tests, neurocognitive tests, and magnetic resonance imaging (MRI). Using voxel-based morphometry (VBM) analysis, we examined the pattern of gray matter (GM) in these participants. We also used ANOVA to detect group differences and partial correlation to explore the potential association between GMV alterations and cognitive tests in comorbid patients. RESULTS: The comorbid patients exhibited significantly smaller GMV in the right middle frontal gyrus (MFG) than the non-comorbid group. Furthermore, the partial correlation analysis showed that GMV of the right MFG was associated with poor executive function (EF) performance in comorbid patients. CONCLUSION: These findings provide valuable insight into the relationship between the alteration of GMV and cognitive dysfunction of MDD patients with comorbid SHypo. Frontiers Media S.A. 2023-02-08 /pmc/articles/PMC9945283/ /pubmed/36845662 http://dx.doi.org/10.3389/fnagi.2023.1106792 Text en Copyright © 2023 Zhao, Du, Zhang, Wang, Xia, Sun, Huang, Zou, Wang, Chen, Zhou, Yan, Tang, Lu and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Zhao, Shuai
Du, Yishan
Zhang, Yu
Wang, Xiaoqin
Xia, Yi
Sun, Hao
Huang, Yinghong
Zou, Haowen
Wang, Xumiao
Chen, Zhilu
Zhou, Hongliang
Yan, Rui
Tang, Hao
Lu, Qing
Yao, Zhijian
Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism
title Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism
title_full Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism
title_fullStr Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism
title_full_unstemmed Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism
title_short Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism
title_sort gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945283/
https://www.ncbi.nlm.nih.gov/pubmed/36845662
http://dx.doi.org/10.3389/fnagi.2023.1106792
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