RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex

BACKGROUND: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies, frequently accompanied by metastasis and aerobic glycolysis. Cancer cells adjust their metabolism by modulating the PKM alternative splicing and facilitating PKM2 isoform expression. Therefore, identifying fac...

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Detalles Bibliográficos
Autores principales: Xu, Debin, Yu, Jichun, Yang, Yuting, Du, Yunyan, Lu, Hongcheng, Zhang, Shouhua, Feng, Qian, Yu, Yi, Hao, Liang, Shao, Jun, Chen, Leifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945352/
https://www.ncbi.nlm.nih.gov/pubmed/36810109
http://dx.doi.org/10.1186/s13578-023-00987-8

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