Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis

Chemodynamic therapy of cancer is limited by insufficient endogenous H(2)O(2) generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM)...

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Detalles Bibliográficos
Autores principales: Zhang, Caiyun, Wang, Peng, Zhang, Ya’ nan, Lu, Pengpeng, Huang, Xiaodan, Wang, Yinfeng, Ran, Lang, Xin, Huan, Xu, Xiaotong, Gao, Wenjuan, Sun, Yu, Zhang, Li, Zhang, Guilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945394/
https://www.ncbi.nlm.nih.gov/pubmed/36810074
http://dx.doi.org/10.1186/s12951-023-01814-5

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