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Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems
The seminal discovery of ribonuclease P (RNase P) and its catalytic RNA by Sidney Altman has not only revolutionized our understanding of life, but also opened new fields for scientific exploration and investigation. This review focuses on human RNase P and its use as a gene-targeting tool, two topi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945436/ https://www.ncbi.nlm.nih.gov/pubmed/36549864 http://dx.doi.org/10.1261/rna.079475.122 |
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author | Jarrous, Nayef Liu, Fenyong |
author_facet | Jarrous, Nayef Liu, Fenyong |
author_sort | Jarrous, Nayef |
collection | PubMed |
description | The seminal discovery of ribonuclease P (RNase P) and its catalytic RNA by Sidney Altman has not only revolutionized our understanding of life, but also opened new fields for scientific exploration and investigation. This review focuses on human RNase P and its use as a gene-targeting tool, two topics initiated in Altman's laboratory. We outline early works on human RNase P as a tRNA processing enzyme and comment on its expanding nonconventional functions in molecular networks of transcription, chromatin remodeling, homology-directed repair, and innate immunity. The important implications and insights from these discoveries on the potential use of RNase P as a gene-targeting tool are presented. This multifunctionality calls to a modified structure–function partitioning of domains in human RNase P, as well as its relative ribonucleoprotein, RNase MRP. The role of these two catalysts in innate immunity is of particular interest in molecular evolution, as this dynamic molecular network could have originated and evolved from primordial enzymes and sensors of RNA, including predecessors of these two ribonucleoproteins. |
format | Online Article Text |
id | pubmed-9945436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99454362023-03-01 Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems Jarrous, Nayef Liu, Fenyong RNA Review The seminal discovery of ribonuclease P (RNase P) and its catalytic RNA by Sidney Altman has not only revolutionized our understanding of life, but also opened new fields for scientific exploration and investigation. This review focuses on human RNase P and its use as a gene-targeting tool, two topics initiated in Altman's laboratory. We outline early works on human RNase P as a tRNA processing enzyme and comment on its expanding nonconventional functions in molecular networks of transcription, chromatin remodeling, homology-directed repair, and innate immunity. The important implications and insights from these discoveries on the potential use of RNase P as a gene-targeting tool are presented. This multifunctionality calls to a modified structure–function partitioning of domains in human RNase P, as well as its relative ribonucleoprotein, RNase MRP. The role of these two catalysts in innate immunity is of particular interest in molecular evolution, as this dynamic molecular network could have originated and evolved from primordial enzymes and sensors of RNA, including predecessors of these two ribonucleoproteins. Cold Spring Harbor Laboratory Press 2023-03 /pmc/articles/PMC9945436/ /pubmed/36549864 http://dx.doi.org/10.1261/rna.079475.122 Text en © 2023 Jarrous and Liu; Published by Cold Spring Harbor Laboratory Press for the RNA Society https://creativecommons.org/licenses/by-nc/4.0/This article, published in RNA, is available undera Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Review Jarrous, Nayef Liu, Fenyong Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems |
title | Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems |
title_full | Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems |
title_fullStr | Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems |
title_full_unstemmed | Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems |
title_short | Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems |
title_sort | human rnase p: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945436/ https://www.ncbi.nlm.nih.gov/pubmed/36549864 http://dx.doi.org/10.1261/rna.079475.122 |
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