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Vitamin D status in healthy Italian school-age children: a single-center cross-sectional study

BACKGROUND: Vitamin D is involved in calcium homeostasis and bone metabolism, although its extra-skeletal actions are also well-known. Low serum 25(OH)D levels are common both in adults and children worldwide. METHODS: The purpose of this cross-sectional study was to determine the distribution of 25...

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Autores principales: Galeazzi, Tiziana, Quattrini, Sara, Pjetraj, Dorina, Gatti, Simona, Monachesi, Chiara, Franceschini, Elisa, Marinelli, Luisita, Catassi, Giulia N., Lionetti, Elena, Catassi, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945672/
https://www.ncbi.nlm.nih.gov/pubmed/36814347
http://dx.doi.org/10.1186/s13052-023-01422-x
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author Galeazzi, Tiziana
Quattrini, Sara
Pjetraj, Dorina
Gatti, Simona
Monachesi, Chiara
Franceschini, Elisa
Marinelli, Luisita
Catassi, Giulia N.
Lionetti, Elena
Catassi, Carlo
author_facet Galeazzi, Tiziana
Quattrini, Sara
Pjetraj, Dorina
Gatti, Simona
Monachesi, Chiara
Franceschini, Elisa
Marinelli, Luisita
Catassi, Giulia N.
Lionetti, Elena
Catassi, Carlo
author_sort Galeazzi, Tiziana
collection PubMed
description BACKGROUND: Vitamin D is involved in calcium homeostasis and bone metabolism, although its extra-skeletal actions are also well-known. Low serum 25(OH)D levels are common both in adults and children worldwide. METHODS: The purpose of this cross-sectional study was to determine the distribution of 25(OH)D levels in a cohort of healthy Italian school-age children, aged 5–10 years, in relationship to determinants of vitamin D deficiency such as season, BMI, gender, age and ethnicity. RESULTS: The mean serum 25(OH) D level was 28.2 ng/mL; the prevalence of 25(OH)D sufficiency (> 30 ng/mL), insufficiency (20–30 ng/mL), deficiency (10–20 ng/mL) and severe deficiency (< 10 ng/mL) was 36%, 37%, 21% and 6% of the study-group population, respectively. The lower serum 25(OH)D values were observed during winter (21.6 ng/mL) and spring (22.9 ng/mL), as compared to summer (46.7 ng/mL) (p < 0.001). Higher BMI z-scores were associated with lower 25(OH)D level while no statistical difference was observed as related to gender and age groups. CONCLUSIONS: Healthy Italian schoolchildren show low 25(OH)D levels, particularly during winter and spring time. Seasonality, ethnicity and overweight/obesity were confirmed to influence the vitamin D status, thus indicating the need for effective initiatives to support adequate vitamin D status in this population group.
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spelling pubmed-99456722023-02-23 Vitamin D status in healthy Italian school-age children: a single-center cross-sectional study Galeazzi, Tiziana Quattrini, Sara Pjetraj, Dorina Gatti, Simona Monachesi, Chiara Franceschini, Elisa Marinelli, Luisita Catassi, Giulia N. Lionetti, Elena Catassi, Carlo Ital J Pediatr Research BACKGROUND: Vitamin D is involved in calcium homeostasis and bone metabolism, although its extra-skeletal actions are also well-known. Low serum 25(OH)D levels are common both in adults and children worldwide. METHODS: The purpose of this cross-sectional study was to determine the distribution of 25(OH)D levels in a cohort of healthy Italian school-age children, aged 5–10 years, in relationship to determinants of vitamin D deficiency such as season, BMI, gender, age and ethnicity. RESULTS: The mean serum 25(OH) D level was 28.2 ng/mL; the prevalence of 25(OH)D sufficiency (> 30 ng/mL), insufficiency (20–30 ng/mL), deficiency (10–20 ng/mL) and severe deficiency (< 10 ng/mL) was 36%, 37%, 21% and 6% of the study-group population, respectively. The lower serum 25(OH)D values were observed during winter (21.6 ng/mL) and spring (22.9 ng/mL), as compared to summer (46.7 ng/mL) (p < 0.001). Higher BMI z-scores were associated with lower 25(OH)D level while no statistical difference was observed as related to gender and age groups. CONCLUSIONS: Healthy Italian schoolchildren show low 25(OH)D levels, particularly during winter and spring time. Seasonality, ethnicity and overweight/obesity were confirmed to influence the vitamin D status, thus indicating the need for effective initiatives to support adequate vitamin D status in this population group. BioMed Central 2023-02-22 /pmc/articles/PMC9945672/ /pubmed/36814347 http://dx.doi.org/10.1186/s13052-023-01422-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Galeazzi, Tiziana
Quattrini, Sara
Pjetraj, Dorina
Gatti, Simona
Monachesi, Chiara
Franceschini, Elisa
Marinelli, Luisita
Catassi, Giulia N.
Lionetti, Elena
Catassi, Carlo
Vitamin D status in healthy Italian school-age children: a single-center cross-sectional study
title Vitamin D status in healthy Italian school-age children: a single-center cross-sectional study
title_full Vitamin D status in healthy Italian school-age children: a single-center cross-sectional study
title_fullStr Vitamin D status in healthy Italian school-age children: a single-center cross-sectional study
title_full_unstemmed Vitamin D status in healthy Italian school-age children: a single-center cross-sectional study
title_short Vitamin D status in healthy Italian school-age children: a single-center cross-sectional study
title_sort vitamin d status in healthy italian school-age children: a single-center cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945672/
https://www.ncbi.nlm.nih.gov/pubmed/36814347
http://dx.doi.org/10.1186/s13052-023-01422-x
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