Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020

Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare facilities...

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Detalles Bibliográficos
Autores principales: Misas, Elizabeth, Deng, John Z, Gold, Jeremy A W, Gade, Lalitha, Nunnally, Natalie S, Georgacopoulos, Ourania, Bentz, Meghan, Berkow, Elizabeth L, Litvintseva, Anastasia P, Chiller, Tom M, Klausner, Jeffrey D, Chow, Nancy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945844/
https://www.ncbi.nlm.nih.gov/pubmed/36715156
http://dx.doi.org/10.1093/mmy/myad012
Descripción
Sumario:Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare facilities in California. Single-nucleotide polymorphism (SNP) differences between patient isolates ranged from 187 to 70 829 SNPs. For five patients with multiple isolates, we calculated the within-host diversities. Three patients had a within-host diversity that ranged from 4 to 10 SNPs and two patients ranged from 2 to 16 977 SNPs. Findings revealed highly diverse A. fumigatus strains among patients and two patterns of diversity for isolates that come from the same patient, low and extremely high diversity.

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