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Cryo-EM structure of human voltage-gated sodium channel Na(v)1.6

Voltage-gated sodium channel Na(v)1.6 plays a crucial role in neuronal firing in the central nervous system (CNS). Aberrant function of Na(v)1.6 may lead to epilepsy and other neurological disorders. Specific inhibitors of Na(v)1.6 thus have therapeutic potentials. Here we present the cryo-EM struct...

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Detalles Bibliográficos
Autores principales:	Fan, Xiao, Huang, Jian, Jin, Xueqin, Yan, Nieng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945969/ https://www.ncbi.nlm.nih.gov/pubmed/36696443 http://dx.doi.org/10.1073/pnas.2220578120

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