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Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning
The motor cortex controls skilled arm movement by recruiting a variety of targets in the nervous system, and it is important to understand the emergent activity in these regions as refinement of a motor skill occurs. One fundamental projection of the motor cortex (M1) is to the cerebellum. However,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946068/ https://www.ncbi.nlm.nih.gov/pubmed/36750360 http://dx.doi.org/10.1523/ENEURO.0011-23.2023 |
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author | Fleischer, Pierson Abbasi, Aamir Fealy, Andrew W. Danielsen, Nathan P. Sandhu, Ramneet Raj, Philip R. Gulati, Tanuj |
author_facet | Fleischer, Pierson Abbasi, Aamir Fealy, Andrew W. Danielsen, Nathan P. Sandhu, Ramneet Raj, Philip R. Gulati, Tanuj |
author_sort | Fleischer, Pierson |
collection | PubMed |
description | The motor cortex controls skilled arm movement by recruiting a variety of targets in the nervous system, and it is important to understand the emergent activity in these regions as refinement of a motor skill occurs. One fundamental projection of the motor cortex (M1) is to the cerebellum. However, the emergent activity in the motor cortex and the cerebellum that appears as a dexterous motor skill is consolidated is incompletely understood. Here, we report on low-frequency oscillatory (LFO) activity that emerges in cortico-cerebellar networks with learning the reach-to-grasp motor skill. We chronically recorded the motor and the cerebellar cortices in rats, which revealed the emergence of coordinated movement-related activity in the local-field potentials as the reaching skill consolidated. Interestingly, we found this emergent activity only in the rats that gained expertise in the task. We found that the local and cross-area spiking activity was coordinated with LFOs in proficient rats. Finally, we also found that these neural dynamics were more prominently expressed during accurate behavior in the M1. This work furthers our understanding on emergent dynamics in the cortico-cerebellar loop that underlie learning and execution of precise skilled movement. |
format | Online Article Text |
id | pubmed-9946068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-99460682023-02-23 Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning Fleischer, Pierson Abbasi, Aamir Fealy, Andrew W. Danielsen, Nathan P. Sandhu, Ramneet Raj, Philip R. Gulati, Tanuj eNeuro Research Article: Confirmation The motor cortex controls skilled arm movement by recruiting a variety of targets in the nervous system, and it is important to understand the emergent activity in these regions as refinement of a motor skill occurs. One fundamental projection of the motor cortex (M1) is to the cerebellum. However, the emergent activity in the motor cortex and the cerebellum that appears as a dexterous motor skill is consolidated is incompletely understood. Here, we report on low-frequency oscillatory (LFO) activity that emerges in cortico-cerebellar networks with learning the reach-to-grasp motor skill. We chronically recorded the motor and the cerebellar cortices in rats, which revealed the emergence of coordinated movement-related activity in the local-field potentials as the reaching skill consolidated. Interestingly, we found this emergent activity only in the rats that gained expertise in the task. We found that the local and cross-area spiking activity was coordinated with LFOs in proficient rats. Finally, we also found that these neural dynamics were more prominently expressed during accurate behavior in the M1. This work furthers our understanding on emergent dynamics in the cortico-cerebellar loop that underlie learning and execution of precise skilled movement. Society for Neuroscience 2023-02-17 /pmc/articles/PMC9946068/ /pubmed/36750360 http://dx.doi.org/10.1523/ENEURO.0011-23.2023 Text en Copyright © 2023 Fleischer et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article: Confirmation Fleischer, Pierson Abbasi, Aamir Fealy, Andrew W. Danielsen, Nathan P. Sandhu, Ramneet Raj, Philip R. Gulati, Tanuj Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning |
title | Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning |
title_full | Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning |
title_fullStr | Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning |
title_full_unstemmed | Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning |
title_short | Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning |
title_sort | emergent low-frequency activity in cortico-cerebellar networks with motor skill learning |
topic | Research Article: Confirmation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946068/ https://www.ncbi.nlm.nih.gov/pubmed/36750360 http://dx.doi.org/10.1523/ENEURO.0011-23.2023 |
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