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Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare

INTRODUCTION: Granuloma annulare (GA) is a non-infectious granulomatous disease that can affect children and adults. Although many studies have been conducted in adult GA patients, the literature on pediatric GA cases is limited. OBJECTIVES: Therefore, this study aimed to examine the demographic, cl...

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Autores principales: Aksu, Ayşe Esra Koku, Erdil, Dilara İlhan, Baş, Vildan Manav, Türk, Cemre Büşra, Leblebici, Cem, Tellal, Ebru Sarıkaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946115/
https://www.ncbi.nlm.nih.gov/pubmed/36633600
http://dx.doi.org/10.5826/dpc.1301a113
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author Aksu, Ayşe Esra Koku
Erdil, Dilara İlhan
Baş, Vildan Manav
Türk, Cemre Büşra
Leblebici, Cem
Tellal, Ebru Sarıkaya
author_facet Aksu, Ayşe Esra Koku
Erdil, Dilara İlhan
Baş, Vildan Manav
Türk, Cemre Büşra
Leblebici, Cem
Tellal, Ebru Sarıkaya
author_sort Aksu, Ayşe Esra Koku
collection PubMed
description INTRODUCTION: Granuloma annulare (GA) is a non-infectious granulomatous disease that can affect children and adults. Although many studies have been conducted in adult GA patients, the literature on pediatric GA cases is limited. OBJECTIVES: Therefore, this study aimed to examine the demographic, clinical, and pathological features of pediatric GA cases. METHODS: This study was performed retrospectively in a single-center tertiary dermatology hospital. Demographic characteristics and clinical and histopathological features were recorded. RESULTS: Forty-one participants were included in this study, of which 66% were females. The mean age was 3.8 ± 2.6 years, and the mean lesion duration was 7.5 ± 10.3 months. The involvement of 78% of the patients was localized, and the remaining 22% was generalized. Asthma (30%) was the most common comorbid disease. Histopathological examination was performed on 21 patients, and the infiltrate pattern was interstitial in 71% of the cases and palisadic in 29%. Generalized distribution, trunk involvement, and concomitant disease tended to be higher in patients with an interstitial pattern than in those with a palisadic pattern. CONCLUSIONS: Atopy and asthma should be questioned in pediatric GA cases. There are differences between involvement, distribution, concomitant disease, and histopathological patterns, which may indicate differences in pathogenesis.
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spelling pubmed-99461152023-02-23 Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare Aksu, Ayşe Esra Koku Erdil, Dilara İlhan Baş, Vildan Manav Türk, Cemre Büşra Leblebici, Cem Tellal, Ebru Sarıkaya Dermatol Pract Concept Original Article INTRODUCTION: Granuloma annulare (GA) is a non-infectious granulomatous disease that can affect children and adults. Although many studies have been conducted in adult GA patients, the literature on pediatric GA cases is limited. OBJECTIVES: Therefore, this study aimed to examine the demographic, clinical, and pathological features of pediatric GA cases. METHODS: This study was performed retrospectively in a single-center tertiary dermatology hospital. Demographic characteristics and clinical and histopathological features were recorded. RESULTS: Forty-one participants were included in this study, of which 66% were females. The mean age was 3.8 ± 2.6 years, and the mean lesion duration was 7.5 ± 10.3 months. The involvement of 78% of the patients was localized, and the remaining 22% was generalized. Asthma (30%) was the most common comorbid disease. Histopathological examination was performed on 21 patients, and the infiltrate pattern was interstitial in 71% of the cases and palisadic in 29%. Generalized distribution, trunk involvement, and concomitant disease tended to be higher in patients with an interstitial pattern than in those with a palisadic pattern. CONCLUSIONS: Atopy and asthma should be questioned in pediatric GA cases. There are differences between involvement, distribution, concomitant disease, and histopathological patterns, which may indicate differences in pathogenesis. Mattioli 1885 2023-01-01 /pmc/articles/PMC9946115/ /pubmed/36633600 http://dx.doi.org/10.5826/dpc.1301a113 Text en ©2023 Koku Aksu et al. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Original Article
Aksu, Ayşe Esra Koku
Erdil, Dilara İlhan
Baş, Vildan Manav
Türk, Cemre Büşra
Leblebici, Cem
Tellal, Ebru Sarıkaya
Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare
title Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare
title_full Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare
title_fullStr Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare
title_full_unstemmed Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare
title_short Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare
title_sort clinical and histopathological evaluation of forty-one cases of pediatric granuloma annulare
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946115/
https://www.ncbi.nlm.nih.gov/pubmed/36633600
http://dx.doi.org/10.5826/dpc.1301a113
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