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Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare
INTRODUCTION: Granuloma annulare (GA) is a non-infectious granulomatous disease that can affect children and adults. Although many studies have been conducted in adult GA patients, the literature on pediatric GA cases is limited. OBJECTIVES: Therefore, this study aimed to examine the demographic, cl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946115/ https://www.ncbi.nlm.nih.gov/pubmed/36633600 http://dx.doi.org/10.5826/dpc.1301a113 |
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author | Aksu, Ayşe Esra Koku Erdil, Dilara İlhan Baş, Vildan Manav Türk, Cemre Büşra Leblebici, Cem Tellal, Ebru Sarıkaya |
author_facet | Aksu, Ayşe Esra Koku Erdil, Dilara İlhan Baş, Vildan Manav Türk, Cemre Büşra Leblebici, Cem Tellal, Ebru Sarıkaya |
author_sort | Aksu, Ayşe Esra Koku |
collection | PubMed |
description | INTRODUCTION: Granuloma annulare (GA) is a non-infectious granulomatous disease that can affect children and adults. Although many studies have been conducted in adult GA patients, the literature on pediatric GA cases is limited. OBJECTIVES: Therefore, this study aimed to examine the demographic, clinical, and pathological features of pediatric GA cases. METHODS: This study was performed retrospectively in a single-center tertiary dermatology hospital. Demographic characteristics and clinical and histopathological features were recorded. RESULTS: Forty-one participants were included in this study, of which 66% were females. The mean age was 3.8 ± 2.6 years, and the mean lesion duration was 7.5 ± 10.3 months. The involvement of 78% of the patients was localized, and the remaining 22% was generalized. Asthma (30%) was the most common comorbid disease. Histopathological examination was performed on 21 patients, and the infiltrate pattern was interstitial in 71% of the cases and palisadic in 29%. Generalized distribution, trunk involvement, and concomitant disease tended to be higher in patients with an interstitial pattern than in those with a palisadic pattern. CONCLUSIONS: Atopy and asthma should be questioned in pediatric GA cases. There are differences between involvement, distribution, concomitant disease, and histopathological patterns, which may indicate differences in pathogenesis. |
format | Online Article Text |
id | pubmed-9946115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-99461152023-02-23 Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare Aksu, Ayşe Esra Koku Erdil, Dilara İlhan Baş, Vildan Manav Türk, Cemre Büşra Leblebici, Cem Tellal, Ebru Sarıkaya Dermatol Pract Concept Original Article INTRODUCTION: Granuloma annulare (GA) is a non-infectious granulomatous disease that can affect children and adults. Although many studies have been conducted in adult GA patients, the literature on pediatric GA cases is limited. OBJECTIVES: Therefore, this study aimed to examine the demographic, clinical, and pathological features of pediatric GA cases. METHODS: This study was performed retrospectively in a single-center tertiary dermatology hospital. Demographic characteristics and clinical and histopathological features were recorded. RESULTS: Forty-one participants were included in this study, of which 66% were females. The mean age was 3.8 ± 2.6 years, and the mean lesion duration was 7.5 ± 10.3 months. The involvement of 78% of the patients was localized, and the remaining 22% was generalized. Asthma (30%) was the most common comorbid disease. Histopathological examination was performed on 21 patients, and the infiltrate pattern was interstitial in 71% of the cases and palisadic in 29%. Generalized distribution, trunk involvement, and concomitant disease tended to be higher in patients with an interstitial pattern than in those with a palisadic pattern. CONCLUSIONS: Atopy and asthma should be questioned in pediatric GA cases. There are differences between involvement, distribution, concomitant disease, and histopathological patterns, which may indicate differences in pathogenesis. Mattioli 1885 2023-01-01 /pmc/articles/PMC9946115/ /pubmed/36633600 http://dx.doi.org/10.5826/dpc.1301a113 Text en ©2023 Koku Aksu et al. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (BY-NC-4.0), https://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Original Article Aksu, Ayşe Esra Koku Erdil, Dilara İlhan Baş, Vildan Manav Türk, Cemre Büşra Leblebici, Cem Tellal, Ebru Sarıkaya Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare |
title | Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare |
title_full | Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare |
title_fullStr | Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare |
title_full_unstemmed | Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare |
title_short | Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare |
title_sort | clinical and histopathological evaluation of forty-one cases of pediatric granuloma annulare |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946115/ https://www.ncbi.nlm.nih.gov/pubmed/36633600 http://dx.doi.org/10.5826/dpc.1301a113 |
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