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Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides

Carbonic anhydrases (CAs) are a zinc metalloenzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton, pivotal for a wide range of biological processes. CAs are involved in numerous pathologies and thus represent valuable drug targets in the treatments of several dis...

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Detalles Bibliográficos
Autores principales: Angeli, Andrea, Ferraroni, Marta, Bonardi, Alessandro, Supuran, Claudiu T., Nocentini, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946301/
https://www.ncbi.nlm.nih.gov/pubmed/36798036
http://dx.doi.org/10.1080/14756366.2023.2178430