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Rotary biomolecular motor-powered supramolecular colloidal motor

Cells orchestrate the motion and force of hundreds of protein motors to perform various mechanical tasks over multiple length scales. However, engineering active biomimetic materials from protein motors that consume energy to propel continuous motion of micrometer-sized assembling systems remains ch...

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Autores principales: Liu, Jun, Wu, Yingjie, Li, Yue, Yang, Ling, Wu, Hao, He, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946340/
https://www.ncbi.nlm.nih.gov/pubmed/36812329
http://dx.doi.org/10.1126/sciadv.abg3015
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author Liu, Jun
Wu, Yingjie
Li, Yue
Yang, Ling
Wu, Hao
He, Qiang
author_facet Liu, Jun
Wu, Yingjie
Li, Yue
Yang, Ling
Wu, Hao
He, Qiang
author_sort Liu, Jun
collection PubMed
description Cells orchestrate the motion and force of hundreds of protein motors to perform various mechanical tasks over multiple length scales. However, engineering active biomimetic materials from protein motors that consume energy to propel continuous motion of micrometer-sized assembling systems remains challenging. Here, we report rotary biomolecular motor-powered supramolecular (RBMS) colloidal motors that are hierarchically assembled from a purified chromatophore membrane containing F(O)F(1)-ATP synthase molecular motors, and an assembled polyelectrolyte microcapsule. The micro-sized RBMS motor with asymmetric distribution of F(O)F(1)-ATPases can autonomously move under light illumination and is collectively powered by hundreds of rotary biomolecular motors. The propulsive mechanism is that a transmembrane proton gradient generated by a photochemical reaction drives F(O)F(1)-ATPases to rotate for ATP biosynthesis, which creates a local chemical field for self-diffusiophoretic force. Such an active supramolecular architecture endowed with motility and biosynthesis offers a promising platform for intelligent colloidal motors resembling the propulsive units in swimming bacteria.
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spelling pubmed-99463402023-02-23 Rotary biomolecular motor-powered supramolecular colloidal motor Liu, Jun Wu, Yingjie Li, Yue Yang, Ling Wu, Hao He, Qiang Sci Adv Physical and Materials Sciences Cells orchestrate the motion and force of hundreds of protein motors to perform various mechanical tasks over multiple length scales. However, engineering active biomimetic materials from protein motors that consume energy to propel continuous motion of micrometer-sized assembling systems remains challenging. Here, we report rotary biomolecular motor-powered supramolecular (RBMS) colloidal motors that are hierarchically assembled from a purified chromatophore membrane containing F(O)F(1)-ATP synthase molecular motors, and an assembled polyelectrolyte microcapsule. The micro-sized RBMS motor with asymmetric distribution of F(O)F(1)-ATPases can autonomously move under light illumination and is collectively powered by hundreds of rotary biomolecular motors. The propulsive mechanism is that a transmembrane proton gradient generated by a photochemical reaction drives F(O)F(1)-ATPases to rotate for ATP biosynthesis, which creates a local chemical field for self-diffusiophoretic force. Such an active supramolecular architecture endowed with motility and biosynthesis offers a promising platform for intelligent colloidal motors resembling the propulsive units in swimming bacteria. American Association for the Advancement of Science 2023-02-22 /pmc/articles/PMC9946340/ /pubmed/36812329 http://dx.doi.org/10.1126/sciadv.abg3015 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Physical and Materials Sciences
Liu, Jun
Wu, Yingjie
Li, Yue
Yang, Ling
Wu, Hao
He, Qiang
Rotary biomolecular motor-powered supramolecular colloidal motor
title Rotary biomolecular motor-powered supramolecular colloidal motor
title_full Rotary biomolecular motor-powered supramolecular colloidal motor
title_fullStr Rotary biomolecular motor-powered supramolecular colloidal motor
title_full_unstemmed Rotary biomolecular motor-powered supramolecular colloidal motor
title_short Rotary biomolecular motor-powered supramolecular colloidal motor
title_sort rotary biomolecular motor-powered supramolecular colloidal motor
topic Physical and Materials Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946340/
https://www.ncbi.nlm.nih.gov/pubmed/36812329
http://dx.doi.org/10.1126/sciadv.abg3015
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