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Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites
Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes ne...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946359/ https://www.ncbi.nlm.nih.gov/pubmed/36812305 http://dx.doi.org/10.1126/sciadv.ade4687 |
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author | Song, Joseph W. Ryu, Hanjun Bai, Wubin Xie, Zhaoqian Vázquez-Guardado, Abraham Nandoliya, Khizar Avila, Raudel Lee, Geumbee Song, Zhen Kim, Jihye Lee, Min-Kyu Liu, Yugang Kim, Mirae Wang, Huifeng Wu, Yixin Yoon, Hong-Joon Kwak, Sung Soo Shin, Jaeho Kwon, Kyeongha Lu, Wei Chen, Xuexian Huang, Yonggang Ameer, Guillermo A. Rogers, John A. |
author_facet | Song, Joseph W. Ryu, Hanjun Bai, Wubin Xie, Zhaoqian Vázquez-Guardado, Abraham Nandoliya, Khizar Avila, Raudel Lee, Geumbee Song, Zhen Kim, Jihye Lee, Min-Kyu Liu, Yugang Kim, Mirae Wang, Huifeng Wu, Yixin Yoon, Hong-Joon Kwak, Sung Soo Shin, Jaeho Kwon, Kyeongha Lu, Wei Chen, Xuexian Huang, Yonggang Ameer, Guillermo A. Rogers, John A. |
author_sort | Song, Joseph W. |
collection | PubMed |
description | Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy. |
format | Online Article Text |
id | pubmed-9946359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-99463592023-02-23 Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites Song, Joseph W. Ryu, Hanjun Bai, Wubin Xie, Zhaoqian Vázquez-Guardado, Abraham Nandoliya, Khizar Avila, Raudel Lee, Geumbee Song, Zhen Kim, Jihye Lee, Min-Kyu Liu, Yugang Kim, Mirae Wang, Huifeng Wu, Yixin Yoon, Hong-Joon Kwak, Sung Soo Shin, Jaeho Kwon, Kyeongha Lu, Wei Chen, Xuexian Huang, Yonggang Ameer, Guillermo A. Rogers, John A. Sci Adv Biomedicine and Life Sciences Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy. American Association for the Advancement of Science 2023-02-22 /pmc/articles/PMC9946359/ /pubmed/36812305 http://dx.doi.org/10.1126/sciadv.ade4687 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Song, Joseph W. Ryu, Hanjun Bai, Wubin Xie, Zhaoqian Vázquez-Guardado, Abraham Nandoliya, Khizar Avila, Raudel Lee, Geumbee Song, Zhen Kim, Jihye Lee, Min-Kyu Liu, Yugang Kim, Mirae Wang, Huifeng Wu, Yixin Yoon, Hong-Joon Kwak, Sung Soo Shin, Jaeho Kwon, Kyeongha Lu, Wei Chen, Xuexian Huang, Yonggang Ameer, Guillermo A. Rogers, John A. Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites |
title | Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites |
title_full | Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites |
title_fullStr | Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites |
title_full_unstemmed | Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites |
title_short | Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites |
title_sort | bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946359/ https://www.ncbi.nlm.nih.gov/pubmed/36812305 http://dx.doi.org/10.1126/sciadv.ade4687 |
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