Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

All cosmetic ingredients registered in Europe must be evaluated for their safety using non-animal methods. Microphysiological systems (MPS) offer a more complex higher tier model to evaluate chemicals. Having established a skin and liver HUMIMIC Chip2 model demonstrating how dosing scenarios impact...

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Detalles Bibliográficos
Autores principales: Tao, Thi-Phuong, Maschmeyer, Ilka, LeCluyse, Edward L., Rogers, Eda, Brandmair, Katrin, Gerlach, Silke, Przibilla, Julia, Kern, Fredy, Genies, Camille, Jacques, Carine, Najjar, Abdulkarim, Schepky, Andreas, Marx, Uwe, Kühnl, Jochen, Hewitt, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946709/
https://www.ncbi.nlm.nih.gov/pubmed/36843954
http://dx.doi.org/10.3389/fphar.2023.1076254

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