Cargando…

Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study

In the U.S. general population, there is a lack of understanding regarding the association between the systemic immune inflammation (SII) index and estimated pulse wave velocity (ePWV), atherogenic index of plasma (AIP), and triglyceride-glucose (TyG) index and cardiovascular disease (CVD). As a res...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Shengjue, Wang, Xiaotong, Zhang, Gang, Tong, Mingyue, Chen, Jian, Zhou, Yufei, Ji, Qian, Liu, Naifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946741/
https://www.ncbi.nlm.nih.gov/pubmed/36846196
http://dx.doi.org/10.1155/2023/1966680
_version_ 1784892398077214720
author Xiao, Shengjue
Wang, Xiaotong
Zhang, Gang
Tong, Mingyue
Chen, Jian
Zhou, Yufei
Ji, Qian
Liu, Naifeng
author_facet Xiao, Shengjue
Wang, Xiaotong
Zhang, Gang
Tong, Mingyue
Chen, Jian
Zhou, Yufei
Ji, Qian
Liu, Naifeng
author_sort Xiao, Shengjue
collection PubMed
description In the U.S. general population, there is a lack of understanding regarding the association between the systemic immune inflammation (SII) index and estimated pulse wave velocity (ePWV), atherogenic index of plasma (AIP), and triglyceride-glucose (TyG) index and cardiovascular disease (CVD). As a result, the objective of our research was to investigate the association between the SII index and ePWV, AIP, and TyG index and incident CVD. We used the National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018 to conduct this study. The correlation between the SII index and ePWV, AIP, and TyG index was examined using generalized additive models with smooth functions. In addition, the association between SII index and triglyceride (TC), high-density lipoprotein cholesterol (HDL-C), and fast glucose (FBG) also were explored. Finally, we further performed multivariable logistic regression analysis, restricted cubic spline (RCS) plots, and subgroup analysis to study the connection between the SII index and CVD. Our analysis included 17389 subjects from the NHANES database. A substantial positive association existed between SII, WV, and the TyG index. In addition, with the increase of the SII index, AIP showed a trend of decreasing first, then rising, and then decreasing. The SII index was inversely and linearly associated with triglyceride (TG), while positively and linearly associated with fast glucose (FBG). However, high-density lipoprotein cholesterol (HDL-C) had a tendency of first declining, then climbing, and finally falling with the rise in the SII index. After adjusting for potential confounders, compared with the lowest quartiles, the odds ratios with 95% confidence intervals for CVD across the quartiles were 0.914 (0.777, 1.074), 0.935 (0.779, 1.096), and 1.112 (0.956, 1.293) for SII index. The RCS plot showed an inverse U-shaped curve relationship between the SII index and CVD. Overall, this study found a strong correlation between a higher SII index and ePWV and the TyG index. Additionally, these cross-sectional data also revealed a U-shaped connection between the SII index and CVD.
format Online
Article
Text
id pubmed-9946741
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-99467412023-02-23 Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study Xiao, Shengjue Wang, Xiaotong Zhang, Gang Tong, Mingyue Chen, Jian Zhou, Yufei Ji, Qian Liu, Naifeng Mediators Inflamm Research Article In the U.S. general population, there is a lack of understanding regarding the association between the systemic immune inflammation (SII) index and estimated pulse wave velocity (ePWV), atherogenic index of plasma (AIP), and triglyceride-glucose (TyG) index and cardiovascular disease (CVD). As a result, the objective of our research was to investigate the association between the SII index and ePWV, AIP, and TyG index and incident CVD. We used the National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018 to conduct this study. The correlation between the SII index and ePWV, AIP, and TyG index was examined using generalized additive models with smooth functions. In addition, the association between SII index and triglyceride (TC), high-density lipoprotein cholesterol (HDL-C), and fast glucose (FBG) also were explored. Finally, we further performed multivariable logistic regression analysis, restricted cubic spline (RCS) plots, and subgroup analysis to study the connection between the SII index and CVD. Our analysis included 17389 subjects from the NHANES database. A substantial positive association existed between SII, WV, and the TyG index. In addition, with the increase of the SII index, AIP showed a trend of decreasing first, then rising, and then decreasing. The SII index was inversely and linearly associated with triglyceride (TG), while positively and linearly associated with fast glucose (FBG). However, high-density lipoprotein cholesterol (HDL-C) had a tendency of first declining, then climbing, and finally falling with the rise in the SII index. After adjusting for potential confounders, compared with the lowest quartiles, the odds ratios with 95% confidence intervals for CVD across the quartiles were 0.914 (0.777, 1.074), 0.935 (0.779, 1.096), and 1.112 (0.956, 1.293) for SII index. The RCS plot showed an inverse U-shaped curve relationship between the SII index and CVD. Overall, this study found a strong correlation between a higher SII index and ePWV and the TyG index. Additionally, these cross-sectional data also revealed a U-shaped connection between the SII index and CVD. Hindawi 2023-02-15 /pmc/articles/PMC9946741/ /pubmed/36846196 http://dx.doi.org/10.1155/2023/1966680 Text en Copyright © 2023 Shengjue Xiao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xiao, Shengjue
Wang, Xiaotong
Zhang, Gang
Tong, Mingyue
Chen, Jian
Zhou, Yufei
Ji, Qian
Liu, Naifeng
Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study
title Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study
title_full Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study
title_fullStr Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study
title_full_unstemmed Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study
title_short Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study
title_sort association of systemic immune inflammation index with estimated pulse wave velocity, atherogenic index of plasma, triglyceride-glucose index, and cardiovascular disease: a large cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946741/
https://www.ncbi.nlm.nih.gov/pubmed/36846196
http://dx.doi.org/10.1155/2023/1966680
work_keys_str_mv AT xiaoshengjue associationofsystemicimmuneinflammationindexwithestimatedpulsewavevelocityatherogenicindexofplasmatriglycerideglucoseindexandcardiovasculardiseasealargecrosssectionalstudy
AT wangxiaotong associationofsystemicimmuneinflammationindexwithestimatedpulsewavevelocityatherogenicindexofplasmatriglycerideglucoseindexandcardiovasculardiseasealargecrosssectionalstudy
AT zhanggang associationofsystemicimmuneinflammationindexwithestimatedpulsewavevelocityatherogenicindexofplasmatriglycerideglucoseindexandcardiovasculardiseasealargecrosssectionalstudy
AT tongmingyue associationofsystemicimmuneinflammationindexwithestimatedpulsewavevelocityatherogenicindexofplasmatriglycerideglucoseindexandcardiovasculardiseasealargecrosssectionalstudy
AT chenjian associationofsystemicimmuneinflammationindexwithestimatedpulsewavevelocityatherogenicindexofplasmatriglycerideglucoseindexandcardiovasculardiseasealargecrosssectionalstudy
AT zhouyufei associationofsystemicimmuneinflammationindexwithestimatedpulsewavevelocityatherogenicindexofplasmatriglycerideglucoseindexandcardiovasculardiseasealargecrosssectionalstudy
AT jiqian associationofsystemicimmuneinflammationindexwithestimatedpulsewavevelocityatherogenicindexofplasmatriglycerideglucoseindexandcardiovasculardiseasealargecrosssectionalstudy
AT liunaifeng associationofsystemicimmuneinflammationindexwithestimatedpulsewavevelocityatherogenicindexofplasmatriglycerideglucoseindexandcardiovasculardiseasealargecrosssectionalstudy