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Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl(4)-induced liver fibrosis

Liver fibrosis is characterised by the activation of hepatic stellate cells (HSCs) and matrix deposition. Accumulating evidence has revealed that the oncogenic protein tyrosine phosphatase Src homology 2 domain-containing phosphatase 2 (SHP2) acts as a therapeutic target of fibrosis. Although severa...

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Detalles Bibliográficos
Autores principales:	Zhang, Yi, Cai, Binhao, Li, Yingying, Xu, Ying, Wang, Yuhan, Zheng, Lulu, Zheng, Xiaochun, Yin, Lina, Chen, Gaozhi, Wang, Yunxiang, Liang, Guang, Chen, Lingfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946977/ https://www.ncbi.nlm.nih.gov/pubmed/36843936 http://dx.doi.org/10.3389/fphar.2023.1098463

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