Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

AIMS/HYPOTHESIS: Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related glycaemic traits. However, little is known about the function of the zinc finger transcription factor Ras-responsive element binding protein 1...

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Detalles Bibliográficos
Autores principales: Mattis, Katia K., Krentz, Nicole A. J., Metzendorf, Christoph, Abaitua, Fernando, Spigelman, Aliya F., Sun, Han, Ikle, Jennifer M., Thaman, Swaraj, Rottner, Antje K., Bautista, Austin, Mazzaferro, Eugenia, Perez-Alcantara, Marta, Manning Fox, Jocelyn E., Torres, Jason M., Wesolowska-Andersen, Agata, Yu, Grace Z., Mahajan, Anubha, Larsson, Anders, MacDonald, Patrick E., Davies, Benjamin, den Hoed, Marcel, Gloyn, Anna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947029/
https://www.ncbi.nlm.nih.gov/pubmed/36633628
http://dx.doi.org/10.1007/s00125-022-05856-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947029/
https://www.ncbi.nlm.nih.gov/pubmed/36633628
http://dx.doi.org/10.1007/s00125-022-05856-6

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