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The Microbiome’s Influence on Head and Neck Cancers

PURPOSE OF REVIEW: Head and neck tumors (HNC) rank sixth among cancers worldwide. Due to their late diagnosis and poor prognosis, they are a clinical challenge. However, recent years have seen a dynamic development of science on the microbiome. The aim of the study is to discuss the role of the micr...

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Autores principales: Dorobisz, Karolina, Dorobisz, Tadeusz, Zatoński, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947050/
https://www.ncbi.nlm.nih.gov/pubmed/36696075
http://dx.doi.org/10.1007/s11912-022-01352-7
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author Dorobisz, Karolina
Dorobisz, Tadeusz
Zatoński, Tomasz
author_facet Dorobisz, Karolina
Dorobisz, Tadeusz
Zatoński, Tomasz
author_sort Dorobisz, Karolina
collection PubMed
description PURPOSE OF REVIEW: Head and neck tumors (HNC) rank sixth among cancers worldwide. Due to their late diagnosis and poor prognosis, they are a clinical challenge. However, recent years have seen a dynamic development of science on the microbiome. The aim of the study is to discuss the role of the microbiome in HNC, the impact of the microbiome on oncogenesis, the course of the disease, as well as on treatment, and its toxicity. RECENT FINDINGS: The microbiome’s influence on oncogenesis, the course of the disease, and the effectiveness of oncological treatment have been confirmed in cancers of the colon, pancreas, lungs, and prostate. There is no solid literature on HNC. Many studies indicate disruption of the oral microbiome and periodontal disease as potential cancer risk factors. Disruption of the microbiome increases radiotherapy’s toxicity, intensifying radiation reactions. SUMMARY: The microbiome plays an important role in cancer. It is a new target in research into new therapies. It may also be a prognostic marker of cancer development. Changes in the composition of the microbiome modulate the effectiveness of oncological treatment. More research is needed on the microbiome and its effects on HNC.
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spelling pubmed-99470502023-02-24 The Microbiome’s Influence on Head and Neck Cancers Dorobisz, Karolina Dorobisz, Tadeusz Zatoński, Tomasz Curr Oncol Rep Head and Neck Cancers (Ey Hanna, Section Editor) PURPOSE OF REVIEW: Head and neck tumors (HNC) rank sixth among cancers worldwide. Due to their late diagnosis and poor prognosis, they are a clinical challenge. However, recent years have seen a dynamic development of science on the microbiome. The aim of the study is to discuss the role of the microbiome in HNC, the impact of the microbiome on oncogenesis, the course of the disease, as well as on treatment, and its toxicity. RECENT FINDINGS: The microbiome’s influence on oncogenesis, the course of the disease, and the effectiveness of oncological treatment have been confirmed in cancers of the colon, pancreas, lungs, and prostate. There is no solid literature on HNC. Many studies indicate disruption of the oral microbiome and periodontal disease as potential cancer risk factors. Disruption of the microbiome increases radiotherapy’s toxicity, intensifying radiation reactions. SUMMARY: The microbiome plays an important role in cancer. It is a new target in research into new therapies. It may also be a prognostic marker of cancer development. Changes in the composition of the microbiome modulate the effectiveness of oncological treatment. More research is needed on the microbiome and its effects on HNC. Springer US 2023-01-25 2023 /pmc/articles/PMC9947050/ /pubmed/36696075 http://dx.doi.org/10.1007/s11912-022-01352-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Head and Neck Cancers (Ey Hanna, Section Editor)
Dorobisz, Karolina
Dorobisz, Tadeusz
Zatoński, Tomasz
The Microbiome’s Influence on Head and Neck Cancers
title The Microbiome’s Influence on Head and Neck Cancers
title_full The Microbiome’s Influence on Head and Neck Cancers
title_fullStr The Microbiome’s Influence on Head and Neck Cancers
title_full_unstemmed The Microbiome’s Influence on Head and Neck Cancers
title_short The Microbiome’s Influence on Head and Neck Cancers
title_sort microbiome’s influence on head and neck cancers
topic Head and Neck Cancers (Ey Hanna, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947050/
https://www.ncbi.nlm.nih.gov/pubmed/36696075
http://dx.doi.org/10.1007/s11912-022-01352-7
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