PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models

BACKGROUND: T cell receptor fusion constructs (TRuC) consist of an antibody-based single chain variable fragment (scFv) fused to a T cell receptor chain (TCR) and allow recognition of cancer cells in an HLA-independent manner. Unlike chimeric antigen receptors (CAR), TRuC are integrated into the TCR...

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Detalles Bibliográficos
Autores principales: Lesch, Stefanie, Nottebrock, Alessia, Rataj, Felicitas, Heise, Constanze, Endres, Stefan, Kobold, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947055/
https://www.ncbi.nlm.nih.gov/pubmed/36409438
http://dx.doi.org/10.1007/s13402-022-00747-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947055/
https://www.ncbi.nlm.nih.gov/pubmed/36409438
http://dx.doi.org/10.1007/s13402-022-00747-9

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