AKT-driven epithelial-mesenchymal transition is affected by copper bioavailability in HER2 negative breast cancer cells via a LOXL2-independent mechanism

BACKGROUND: The main mechanism underlying cancer dissemination is the epithelial to mesenchymal transition (EMT). This process is orchestrated by cytokines like TGFβ, involving “non-canonical” AKT- or STAT3-driven pathways. Recently, the alteration of copper homeostasis seems involved in the onset a...

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Detalles Bibliográficos
Autores principales: Vitaliti, Alessandra, Roccatani, Ilenia, Iorio, Egidio, Perta, Nunzio, Gismondi, Angelo, Chirico, Mattea, Pisanu, Maria Elena, Di Marino, Daniele, Canini, Antonella, De Luca, Anastasia, Rossi, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947069/
https://www.ncbi.nlm.nih.gov/pubmed/36454513
http://dx.doi.org/10.1007/s13402-022-00738-w

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