Five new limonoids isolated from Walsura robusta

Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1–4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR...

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Autores principales: Hou, Li, Mei, Cui-Xuan, Yuan, Chun-Mao, Tang, Gui-Hua, Chen, Duo-Zhi, Zhao, Qing, He, Hong-Ping, Cao, Ming-Ming, Hao, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947198/
https://www.ncbi.nlm.nih.gov/pubmed/36813988
http://dx.doi.org/10.1007/s13659-023-00371-6
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author Hou, Li
Mei, Cui-Xuan
Yuan, Chun-Mao
Tang, Gui-Hua
Chen, Duo-Zhi
Zhao, Qing
He, Hong-Ping
Cao, Ming-Ming
Hao, Xiao-Jiang
author_facet Hou, Li
Mei, Cui-Xuan
Yuan, Chun-Mao
Tang, Gui-Hua
Chen, Duo-Zhi
Zhao, Qing
He, Hong-Ping
Cao, Ming-Ming
Hao, Xiao-Jiang
author_sort Hou, Li
collection PubMed
description Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1–4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1–6 exhibited good cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00371-6.
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spelling pubmed-99471982023-02-24 Five new limonoids isolated from Walsura robusta Hou, Li Mei, Cui-Xuan Yuan, Chun-Mao Tang, Gui-Hua Chen, Duo-Zhi Zhao, Qing He, Hong-Ping Cao, Ming-Ming Hao, Xiao-Jiang Nat Prod Bioprospect Original Article Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1–4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1–6 exhibited good cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00371-6. Springer Nature Singapore 2023-02-23 /pmc/articles/PMC9947198/ /pubmed/36813988 http://dx.doi.org/10.1007/s13659-023-00371-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Hou, Li
Mei, Cui-Xuan
Yuan, Chun-Mao
Tang, Gui-Hua
Chen, Duo-Zhi
Zhao, Qing
He, Hong-Ping
Cao, Ming-Ming
Hao, Xiao-Jiang
Five new limonoids isolated from Walsura robusta
title Five new limonoids isolated from Walsura robusta
title_full Five new limonoids isolated from Walsura robusta
title_fullStr Five new limonoids isolated from Walsura robusta
title_full_unstemmed Five new limonoids isolated from Walsura robusta
title_short Five new limonoids isolated from Walsura robusta
title_sort five new limonoids isolated from walsura robusta
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947198/
https://www.ncbi.nlm.nih.gov/pubmed/36813988
http://dx.doi.org/10.1007/s13659-023-00371-6
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