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Optimization of recombinant antibody production based on the vector design and the level of metabolites for generation of Ig- producing stable cell lines
BACKGROUND: The biopharmaceutical industry is significantly growing worldwide, and the Chinese hamster ovary (CHO) cells are used as a main expression host for the production of recombinant monoclonal antibodies. Various metabolic engineering approaches have been investigated to generate cell lines...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947203/ https://www.ncbi.nlm.nih.gov/pubmed/36811683 http://dx.doi.org/10.1186/s43141-023-00474-0 |