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Optimization of recombinant antibody production based on the vector design and the level of metabolites for generation of Ig- producing stable cell lines

BACKGROUND: The biopharmaceutical industry is significantly growing worldwide, and the Chinese hamster ovary (CHO) cells are used as a main expression host for the production of recombinant monoclonal antibodies. Various metabolic engineering approaches have been investigated to generate cell lines...

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Detalles Bibliográficos
Autores principales:	Toporova, V. A., Argentova, V. V., Aliev, T. K., Panina, A. A., Dolgikh, D. A., Kirpichnikov, M. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947203/ https://www.ncbi.nlm.nih.gov/pubmed/36811683 http://dx.doi.org/10.1186/s43141-023-00474-0

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