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Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders

β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors. The cytoskeletal system plays a role in various cellular processes, including intracellular transport, cell division, organization of organelles...

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Autores principales: Szénási, Tibor, Turu, Gábor, Hunyady, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947276/
https://www.ncbi.nlm.nih.gov/pubmed/36843600
http://dx.doi.org/10.3389/fendo.2023.957981
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author Szénási, Tibor
Turu, Gábor
Hunyady, László
author_facet Szénási, Tibor
Turu, Gábor
Hunyady, László
author_sort Szénási, Tibor
collection PubMed
description β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors. The cytoskeletal system plays a role in various cellular processes, including intracellular transport, cell division, organization of organelles, and cell cycle. The interactome of β-arrestins includes the major proteins of the three main cytoskeletal systems: tubulins for microtubules, actins for the actin filaments, and vimentin for intermediate filaments. β-arrestins bind to microtubules and regulate their activity by recruiting signaling proteins and interacting with assembly proteins that regulate the actin cytoskeleton and the intermediate filaments. Altered regulation of the cytoskeletal system plays an essential role in the development of Alzheimer’s, Parkinson’s and other neurodegenerative diseases. Thus, β-arrestins, which interact with the cytoskeleton, were implicated in the pathogenesis progression of these diseases and are potential targets for the treatment of neurodegenerative disorders in the future.
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spelling pubmed-99472762023-02-24 Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders Szénási, Tibor Turu, Gábor Hunyady, László Front Endocrinol (Lausanne) Endocrinology β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors. The cytoskeletal system plays a role in various cellular processes, including intracellular transport, cell division, organization of organelles, and cell cycle. The interactome of β-arrestins includes the major proteins of the three main cytoskeletal systems: tubulins for microtubules, actins for the actin filaments, and vimentin for intermediate filaments. β-arrestins bind to microtubules and regulate their activity by recruiting signaling proteins and interacting with assembly proteins that regulate the actin cytoskeleton and the intermediate filaments. Altered regulation of the cytoskeletal system plays an essential role in the development of Alzheimer’s, Parkinson’s and other neurodegenerative diseases. Thus, β-arrestins, which interact with the cytoskeleton, were implicated in the pathogenesis progression of these diseases and are potential targets for the treatment of neurodegenerative disorders in the future. Frontiers Media S.A. 2023-02-09 /pmc/articles/PMC9947276/ /pubmed/36843600 http://dx.doi.org/10.3389/fendo.2023.957981 Text en Copyright © 2023 Szénási, Turu and Hunyady https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Szénási, Tibor
Turu, Gábor
Hunyady, László
Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders
title Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders
title_full Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders
title_fullStr Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders
title_full_unstemmed Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders
title_short Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders
title_sort interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947276/
https://www.ncbi.nlm.nih.gov/pubmed/36843600
http://dx.doi.org/10.3389/fendo.2023.957981
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