Post-transplant cyclophosphamide prevents xenogeneic graft-versus-host disease while depleting proliferating regulatory T cells

Graft-versus-host disease (GVHD) remains a serious limitation of allogeneic hematopoietic cell transplantation (allo-HCT). While post-transplant administration of cyclophosphamide (PTCy) is increasingly used as GVHD prophylaxis, its precise mechanisms of action and its impact on graft-versus-leukemi...

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Detalles Bibliográficos
Autores principales: Ritacco, Caroline, Köse, Murat Cem, Courtois, Justine, Canti, Lorenzo, Beguin, Charline, Dubois, Sophie, Vandenhove, Benoît, Servais, Sophie, Caers, Jo, Beguin, Yves, Ehx, Grégory, Baron, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947306/
https://www.ncbi.nlm.nih.gov/pubmed/36843851
http://dx.doi.org/10.1016/j.isci.2023.106085

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