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Anti-angiogenic collagen IV-derived peptide target engagement with α(v)β(3) and α(5)β(1) in ocular neovascularization models

AXT107, a collagen-derived peptide that binds integrins α(v)β(3) and α(5)β(1) with high affinity, suppresses vascular endothelial growth factor (VEGF) signaling, promotes angiopoietin 2-induced Tie2 activation, and suppresses neovascularization (NV) and vascular leakage. Immunohistochemical staining...

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Detalles Bibliográficos
Autores principales:	Lima e Silva, Raquel, Mirando, Adam C., Tzeng, Stephany Y., Green, Jordan J., Popel, Aleksander S., Pandey, Niranjan B., Campochiaro, Peter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947312/ https://www.ncbi.nlm.nih.gov/pubmed/36844452 http://dx.doi.org/10.1016/j.isci.2023.106078

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