Hypermethylation of Smad7 in CD4(+) T cells is associated with the disease activity of rheumatoid arthritis

BACKGROUND: Smad7 is protective in a mouse model of rheumatoid arthritis. Here we investigated whether Smad7-expressing CD4(+) T cells and the methylation of Smad7 gene in CD4(+) T cells contribute to the disease activity of RA in patients. METHODS: Peripheral CD4(+) T cells were collected from 35 h...

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Detalles Bibliográficos
Autores principales: Hu, Yiping, Xu, Bihua, He, Juan, Shan, Hongying, Zhou, Gengmin, Wang, Deli, Bai, Lu, Shang, Hongxi, Nie, Liping, Pan, Fan, Lan, Hui Yao, Wang, Qingwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947360/
https://www.ncbi.nlm.nih.gov/pubmed/36845150
http://dx.doi.org/10.3389/fimmu.2023.1104881

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