Role of rodents in the zoonotic transmission of giardiasis

Four species of Giardia out of nine have been identified in rodents based on molecular data: G. muris, G. microti, G. cricetidarum, and G. duodenalis. A total of seven G. duodenalis assemblages (A, B, C, D, E, F, G) have been identified in rodents to date. The zoonotic assemblages A and B are responsible for 74.88% (480/641) of the total identified genotypes in rodents by statistic. For sub-assemblage A in humans, AII is responsible for 71.02% (1397/1967) of the identified sub-assemblages, followed by AI with 26.39% (519/1967) and AIII with 1.17% (23/1967), indicating a significantly greater zoonotic potential for G. duodenalis infections in humans originating from animals. For sub-assemblages of type A in rodents, AI was identified in 86.89% (53/61), and AII in 4.92% (3/61). For assemblage B, 60.84% (390/641) were identified in rodents as having zoonotic potential to humans. In environmental samples, the zoonotic assemblages A and B were responsible for 83.81% (533/636) in water samples, 86.96% (140/161) in fresh produce samples, and 100% (8/8) in soil samples. The same zoonotic potential assemblage A or B simultaneously identified in humans, rodents, and environment samples had potential zoonotic transmission between humans and animals via a synanthropic environment. The infections and zoonotic potential for G. duodenalis were higher in farmed rodents and pet rodents than that in zoo, lab, and wild rodents. In conclusion, the role of rodents in zoonotic transmission of giardiasis should be noticed. In addition to rodents, dogs, cats, wild animals, and livestock could be involved in the zoonotic transmission cycle. This study aims to explore the current situation of giardiasis in rodents and seeks to delineate the role of rodents in the zoonotic transmission of giardiasis from the One Health perspective.