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Dietary precursors and cardiovascular disease: A Mendelian randomization study
BACKGROUND: The Dietary precursor has been identified as a contributor in the development of cardiovascular disease. However, it is inconsistent if dietary precursors could affect the process of cardiovascular disease. METHODS: Here we performed Mendelian randomization (MR) analysis of the data from...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947469/ https://www.ncbi.nlm.nih.gov/pubmed/36844729 http://dx.doi.org/10.3389/fcvm.2023.1061119 |
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author | Jing, Wangwei Huang, Shushi Xiang, Pingping Huang, Jiniu Yu, Hong |
author_facet | Jing, Wangwei Huang, Shushi Xiang, Pingping Huang, Jiniu Yu, Hong |
author_sort | Jing, Wangwei |
collection | PubMed |
description | BACKGROUND: The Dietary precursor has been identified as a contributor in the development of cardiovascular disease. However, it is inconsistent if dietary precursors could affect the process of cardiovascular disease. METHODS: Here we performed Mendelian randomization (MR) analysis of the data from genome-wide association study of European ancestry to evaluate the independent effects of three dietary precursors on cardiovascular disease (CVD), myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF), and valvular disease (VHD). Inverse variance weighting method was used for the MR estimation. Sensitivity was determined by MR-PRESSO analysis, weighted median analysis, MR-Egger analysis, and Leave-one-out analysis. RESULTS: We found that elevated choline level had a causal relationship with VHD [odds ratio (OR) = 1.087, 95% confidence interval (CI), 1.003–1.178, P = 0.041] and MI (OR = 1.250, 95% CI, 1.041–1.501, P = 0.017) by single-variable MR analysis. Furthermore, elevated carnitine level was associated with MI (OR = 5.007, 95% CI, 1.693–14.808, P = 0.004) and HF (OR = 2.176, 95% CI, 1.252–3.780, P = 0.006) risk. In addition, elevated phosphatidylcholine level can increase the risk of MI (OR = 1.197, 95% CI, 1.026–1.397, P = 0.022). CONCLUSION: Our data show that choline increases VHD or MI risk, carnitine increases the risk of MI or HF, and phosphatidylcholine increases HF risk. These findings suggest the possibility that decrease in choline level in circulation may be able to reduce overall VHD or MI risk, reduce in carnitine level could be decrease MI and HF risks as well as decrease in phosphatidylcholine could reduce MI risk. |
format | Online Article Text |
id | pubmed-9947469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99474692023-02-24 Dietary precursors and cardiovascular disease: A Mendelian randomization study Jing, Wangwei Huang, Shushi Xiang, Pingping Huang, Jiniu Yu, Hong Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: The Dietary precursor has been identified as a contributor in the development of cardiovascular disease. However, it is inconsistent if dietary precursors could affect the process of cardiovascular disease. METHODS: Here we performed Mendelian randomization (MR) analysis of the data from genome-wide association study of European ancestry to evaluate the independent effects of three dietary precursors on cardiovascular disease (CVD), myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF), and valvular disease (VHD). Inverse variance weighting method was used for the MR estimation. Sensitivity was determined by MR-PRESSO analysis, weighted median analysis, MR-Egger analysis, and Leave-one-out analysis. RESULTS: We found that elevated choline level had a causal relationship with VHD [odds ratio (OR) = 1.087, 95% confidence interval (CI), 1.003–1.178, P = 0.041] and MI (OR = 1.250, 95% CI, 1.041–1.501, P = 0.017) by single-variable MR analysis. Furthermore, elevated carnitine level was associated with MI (OR = 5.007, 95% CI, 1.693–14.808, P = 0.004) and HF (OR = 2.176, 95% CI, 1.252–3.780, P = 0.006) risk. In addition, elevated phosphatidylcholine level can increase the risk of MI (OR = 1.197, 95% CI, 1.026–1.397, P = 0.022). CONCLUSION: Our data show that choline increases VHD or MI risk, carnitine increases the risk of MI or HF, and phosphatidylcholine increases HF risk. These findings suggest the possibility that decrease in choline level in circulation may be able to reduce overall VHD or MI risk, reduce in carnitine level could be decrease MI and HF risks as well as decrease in phosphatidylcholine could reduce MI risk. Frontiers Media S.A. 2023-02-09 /pmc/articles/PMC9947469/ /pubmed/36844729 http://dx.doi.org/10.3389/fcvm.2023.1061119 Text en Copyright © 2023 Jing, Huang, Xiang, Huang and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Jing, Wangwei Huang, Shushi Xiang, Pingping Huang, Jiniu Yu, Hong Dietary precursors and cardiovascular disease: A Mendelian randomization study |
title | Dietary precursors and cardiovascular disease: A Mendelian randomization study |
title_full | Dietary precursors and cardiovascular disease: A Mendelian randomization study |
title_fullStr | Dietary precursors and cardiovascular disease: A Mendelian randomization study |
title_full_unstemmed | Dietary precursors and cardiovascular disease: A Mendelian randomization study |
title_short | Dietary precursors and cardiovascular disease: A Mendelian randomization study |
title_sort | dietary precursors and cardiovascular disease: a mendelian randomization study |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947469/ https://www.ncbi.nlm.nih.gov/pubmed/36844729 http://dx.doi.org/10.3389/fcvm.2023.1061119 |
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