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A survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: A population analysis based on SEER database

BACKGROUND: The prognosis of diffuse low-grade gliomas (DLGGs, WHO grade 2) is highly variable, making it difficult to evaluate individual patient outcomes. In this study, we used common clinical characteristics to construct a predictive model with multiple indicators. METHODS: We identified 2459 pa...

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Autores principales: Ao, Lei, Shi, Dongjie, Liu, Dan, Yu, Hua, Xu, Li, Xia, Yongzhi, Hao, Shilei, Yang, Yaying, Zhong, Wenjie, Zhou, Junjie, Xia, Haijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947492/
https://www.ncbi.nlm.nih.gov/pubmed/36845716
http://dx.doi.org/10.3389/fonc.2023.963688
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author Ao, Lei
Shi, Dongjie
Liu, Dan
Yu, Hua
Xu, Li
Xia, Yongzhi
Hao, Shilei
Yang, Yaying
Zhong, Wenjie
Zhou, Junjie
Xia, Haijian
author_facet Ao, Lei
Shi, Dongjie
Liu, Dan
Yu, Hua
Xu, Li
Xia, Yongzhi
Hao, Shilei
Yang, Yaying
Zhong, Wenjie
Zhou, Junjie
Xia, Haijian
author_sort Ao, Lei
collection PubMed
description BACKGROUND: The prognosis of diffuse low-grade gliomas (DLGGs, WHO grade 2) is highly variable, making it difficult to evaluate individual patient outcomes. In this study, we used common clinical characteristics to construct a predictive model with multiple indicators. METHODS: We identified 2459 patients diagnosed with astrocytoma and oligodendroglioma from 2000 to 2018 in the SEER database. After removing invalid information, we randomly divided the cleaned patient data into training and validation groups. We performed univariate and multivariate Cox regression analyses and constructed a nomogram. Receiver operating characteristic (ROC) curve, c-index, calibration curve, and subgroup analyses were used to assess the accuracy of the nomogram by internal and external validation. RESULTS: After univariate and multivariate Cox regression analyses, we identified seven independent prognostic factors, namely, age (P<0.001), sex (P<0.05), histological type (P<0.001), surgery (P<0.01), radiotherapy (P<0.001), chemotherapy (P<0.05) and tumor size (P<0.001). The ROC curve, c-index, calibration curve, and subgroup analyses of the training group and the validation group showed that the model had good predictive value. The nomogram for DLGGs predicted patients’ 3-, 5- and 10-year survival rates based on these seven variables. CONCLUSIONS: The nomogram constructed with common clinical characteristics has good prognostic value for patients with DLGGs and can help physicians make clinical decisions.
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spelling pubmed-99474922023-02-24 A survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: A population analysis based on SEER database Ao, Lei Shi, Dongjie Liu, Dan Yu, Hua Xu, Li Xia, Yongzhi Hao, Shilei Yang, Yaying Zhong, Wenjie Zhou, Junjie Xia, Haijian Front Oncol Oncology BACKGROUND: The prognosis of diffuse low-grade gliomas (DLGGs, WHO grade 2) is highly variable, making it difficult to evaluate individual patient outcomes. In this study, we used common clinical characteristics to construct a predictive model with multiple indicators. METHODS: We identified 2459 patients diagnosed with astrocytoma and oligodendroglioma from 2000 to 2018 in the SEER database. After removing invalid information, we randomly divided the cleaned patient data into training and validation groups. We performed univariate and multivariate Cox regression analyses and constructed a nomogram. Receiver operating characteristic (ROC) curve, c-index, calibration curve, and subgroup analyses were used to assess the accuracy of the nomogram by internal and external validation. RESULTS: After univariate and multivariate Cox regression analyses, we identified seven independent prognostic factors, namely, age (P<0.001), sex (P<0.05), histological type (P<0.001), surgery (P<0.01), radiotherapy (P<0.001), chemotherapy (P<0.05) and tumor size (P<0.001). The ROC curve, c-index, calibration curve, and subgroup analyses of the training group and the validation group showed that the model had good predictive value. The nomogram for DLGGs predicted patients’ 3-, 5- and 10-year survival rates based on these seven variables. CONCLUSIONS: The nomogram constructed with common clinical characteristics has good prognostic value for patients with DLGGs and can help physicians make clinical decisions. Frontiers Media S.A. 2023-02-09 /pmc/articles/PMC9947492/ /pubmed/36845716 http://dx.doi.org/10.3389/fonc.2023.963688 Text en Copyright © 2023 Ao, Shi, Liu, Yu, Xu, Xia, Hao, Yang, Zhong, Zhou and Xia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ao, Lei
Shi, Dongjie
Liu, Dan
Yu, Hua
Xu, Li
Xia, Yongzhi
Hao, Shilei
Yang, Yaying
Zhong, Wenjie
Zhou, Junjie
Xia, Haijian
A survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: A population analysis based on SEER database
title A survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: A population analysis based on SEER database
title_full A survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: A population analysis based on SEER database
title_fullStr A survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: A population analysis based on SEER database
title_full_unstemmed A survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: A population analysis based on SEER database
title_short A survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: A population analysis based on SEER database
title_sort survival nomogram model constructed with common clinical characteristics to assist clinical decisions for diffuse low-grade gliomas: a population analysis based on seer database
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947492/
https://www.ncbi.nlm.nih.gov/pubmed/36845716
http://dx.doi.org/10.3389/fonc.2023.963688
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