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Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex
Higher mammals are able to simultaneously learn and perform a wide array of complex behaviors, which raises questions about how the neural representations of multiple tasks coexist within the same neural network. Do neurons play invariant roles across different tasks? Alternatively, do the same neur...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947505/ https://www.ncbi.nlm.nih.gov/pubmed/36846499 http://dx.doi.org/10.3389/fnsys.2023.1049062 |
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author | Awan, Muhammad Ali Haider Mushiake, Hajime Matsuzaka, Yoshiya |
author_facet | Awan, Muhammad Ali Haider Mushiake, Hajime Matsuzaka, Yoshiya |
author_sort | Awan, Muhammad Ali Haider |
collection | PubMed |
description | Higher mammals are able to simultaneously learn and perform a wide array of complex behaviors, which raises questions about how the neural representations of multiple tasks coexist within the same neural network. Do neurons play invariant roles across different tasks? Alternatively, do the same neurons play different roles in different tasks? To address these questions, we examined neuronal activity in the posterior medial prefrontal cortex of primates while they were performing two versions of arm-reaching tasks that required the selection of multiple behavioral tactics (i.e., the internal protocol of action selection), a critical requirement for the activation of this area. During the performance of these tasks, neurons in the pmPFC exhibited selective activity for the tactics, visuospatial information, action, or their combination. Surprisingly, in 82% of the tactics-selective neurons, the selective activity appeared in a particular task but not in both. Such task-specific neuronal representation appeared in 72% of the action-selective neurons. In addition, 95% of the neurons representing visuospatial information showed such activity exclusively in one task but not in both. Our findings indicate that the same neurons can play different roles across different tasks even though the tasks require common information, supporting the latter hypothesis. |
format | Online Article Text |
id | pubmed-9947505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99475052023-02-24 Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex Awan, Muhammad Ali Haider Mushiake, Hajime Matsuzaka, Yoshiya Front Syst Neurosci Neuroscience Higher mammals are able to simultaneously learn and perform a wide array of complex behaviors, which raises questions about how the neural representations of multiple tasks coexist within the same neural network. Do neurons play invariant roles across different tasks? Alternatively, do the same neurons play different roles in different tasks? To address these questions, we examined neuronal activity in the posterior medial prefrontal cortex of primates while they were performing two versions of arm-reaching tasks that required the selection of multiple behavioral tactics (i.e., the internal protocol of action selection), a critical requirement for the activation of this area. During the performance of these tasks, neurons in the pmPFC exhibited selective activity for the tactics, visuospatial information, action, or their combination. Surprisingly, in 82% of the tactics-selective neurons, the selective activity appeared in a particular task but not in both. Such task-specific neuronal representation appeared in 72% of the action-selective neurons. In addition, 95% of the neurons representing visuospatial information showed such activity exclusively in one task but not in both. Our findings indicate that the same neurons can play different roles across different tasks even though the tasks require common information, supporting the latter hypothesis. Frontiers Media S.A. 2023-02-09 /pmc/articles/PMC9947505/ /pubmed/36846499 http://dx.doi.org/10.3389/fnsys.2023.1049062 Text en Copyright © 2023 Awan, Mushiake and Matsuzaka. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Awan, Muhammad Ali Haider Mushiake, Hajime Matsuzaka, Yoshiya Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex |
title | Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex |
title_full | Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex |
title_fullStr | Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex |
title_full_unstemmed | Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex |
title_short | Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex |
title_sort | non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947505/ https://www.ncbi.nlm.nih.gov/pubmed/36846499 http://dx.doi.org/10.3389/fnsys.2023.1049062 |
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