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Identification of the molecular determinants of antagonist potency in the allosteric binding pocket of human P2X4
P2X receptors are a family of ATP-gated cation channels comprising seven subtypes in mammals, which play key roles in nerve transmission, pain sensation and inflammation. The P2X4 receptor in particular has attracted significant interest from pharmaceutical companies due to its physiological roles i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947563/ https://www.ncbi.nlm.nih.gov/pubmed/36843952 http://dx.doi.org/10.3389/fphar.2023.1101023 |