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Safety and Efficacy of Carbon Nanoparticle-Labeled Lymph Node Dissection in Radical Resection of Gastric Cancer: A Systematic Review and Meta-Analysis
Objective: In this meta-analysis, we investigated the safety and efficacy of carbon nanoparticle (CNP) trace-guided lymph node (LN) dissection during radical gastrectomy. Methods: Literature on CNP tracing compared with non-CNP tracing in radical gastric cancer (GC) surgery was searched from PubMed,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947691/ https://www.ncbi.nlm.nih.gov/pubmed/36877933 http://dx.doi.org/10.1177/15330338231154094 |
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author | Zhu, Chenglou Wang, Junhong Wu, Qiong Da, Mingxu |
author_facet | Zhu, Chenglou Wang, Junhong Wu, Qiong Da, Mingxu |
author_sort | Zhu, Chenglou |
collection | PubMed |
description | Objective: In this meta-analysis, we investigated the safety and efficacy of carbon nanoparticle (CNP) trace-guided lymph node (LN) dissection during radical gastrectomy. Methods: Literature on CNP tracing compared with non-CNP tracing in radical gastric cancer (GC) surgery was searched from PubMed, EMBASE (Ovid platform), Web of Science, and the Cochrane Library from the establishment of the library until October 2022. This meta-analysis was performed according to the preferred reporting items for systematic reviews and meta-analysis guidelines. Available data regarding the number of LNs dissected, number of metastatic LNs dissected, other surgical outcomes, and postoperative complications were analyzed in a pooled manner. Stata software (version 12.0) was used for the present meta-analysis. Results: This analysis included 7 studies with a total of 1827 GC patients (551 and 1276 in the CNP and non-CNP groups, respectively). The results of the meta-analysis showed that the CNP group had more intraoperative LNs detected [weighted mean difference (WMD) = 6.67, 95% confidence interval (CI): 3.71–9.62], more LN metastases (WMD = 1.60, 95% CI: 0.09-3.12), and less intraoperative bleeding (WMD = 11.33, 95% CI: 6.30-16.37) than the non-CNP group, all with statistically significant differences (P < .05). For postoperative complications (odds ratio [OR] = 0.88, 95% CI: 0.52-1.48) and operative time (WMD = −11.60, 95% CI: −40.53-17.34), there was no statistically significant difference between the 2 groups (P > 0.05). Conclusions: CNP was a significant tracer for the LNs of GC. It increased the number of LNs harvested while reducing intraoperative blood loss, without increasing the operative time or postoperative complications. CNP tracer-guided lymphadenectomy is considered safe and effective for gastrectomy. |
format | Online Article Text |
id | pubmed-9947691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-99476912023-02-24 Safety and Efficacy of Carbon Nanoparticle-Labeled Lymph Node Dissection in Radical Resection of Gastric Cancer: A Systematic Review and Meta-Analysis Zhu, Chenglou Wang, Junhong Wu, Qiong Da, Mingxu Technol Cancer Res Treat Screening, Diagnosis, and Treatment of Gastric Cancer Objective: In this meta-analysis, we investigated the safety and efficacy of carbon nanoparticle (CNP) trace-guided lymph node (LN) dissection during radical gastrectomy. Methods: Literature on CNP tracing compared with non-CNP tracing in radical gastric cancer (GC) surgery was searched from PubMed, EMBASE (Ovid platform), Web of Science, and the Cochrane Library from the establishment of the library until October 2022. This meta-analysis was performed according to the preferred reporting items for systematic reviews and meta-analysis guidelines. Available data regarding the number of LNs dissected, number of metastatic LNs dissected, other surgical outcomes, and postoperative complications were analyzed in a pooled manner. Stata software (version 12.0) was used for the present meta-analysis. Results: This analysis included 7 studies with a total of 1827 GC patients (551 and 1276 in the CNP and non-CNP groups, respectively). The results of the meta-analysis showed that the CNP group had more intraoperative LNs detected [weighted mean difference (WMD) = 6.67, 95% confidence interval (CI): 3.71–9.62], more LN metastases (WMD = 1.60, 95% CI: 0.09-3.12), and less intraoperative bleeding (WMD = 11.33, 95% CI: 6.30-16.37) than the non-CNP group, all with statistically significant differences (P < .05). For postoperative complications (odds ratio [OR] = 0.88, 95% CI: 0.52-1.48) and operative time (WMD = −11.60, 95% CI: −40.53-17.34), there was no statistically significant difference between the 2 groups (P > 0.05). Conclusions: CNP was a significant tracer for the LNs of GC. It increased the number of LNs harvested while reducing intraoperative blood loss, without increasing the operative time or postoperative complications. CNP tracer-guided lymphadenectomy is considered safe and effective for gastrectomy. SAGE Publications 2023-02-21 /pmc/articles/PMC9947691/ /pubmed/36877933 http://dx.doi.org/10.1177/15330338231154094 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Screening, Diagnosis, and Treatment of Gastric Cancer Zhu, Chenglou Wang, Junhong Wu, Qiong Da, Mingxu Safety and Efficacy of Carbon Nanoparticle-Labeled Lymph Node Dissection in Radical Resection of Gastric Cancer: A Systematic Review and Meta-Analysis |
title | Safety and Efficacy of Carbon Nanoparticle-Labeled Lymph Node
Dissection in Radical Resection of Gastric Cancer: A Systematic Review and
Meta-Analysis |
title_full | Safety and Efficacy of Carbon Nanoparticle-Labeled Lymph Node
Dissection in Radical Resection of Gastric Cancer: A Systematic Review and
Meta-Analysis |
title_fullStr | Safety and Efficacy of Carbon Nanoparticle-Labeled Lymph Node
Dissection in Radical Resection of Gastric Cancer: A Systematic Review and
Meta-Analysis |
title_full_unstemmed | Safety and Efficacy of Carbon Nanoparticle-Labeled Lymph Node
Dissection in Radical Resection of Gastric Cancer: A Systematic Review and
Meta-Analysis |
title_short | Safety and Efficacy of Carbon Nanoparticle-Labeled Lymph Node
Dissection in Radical Resection of Gastric Cancer: A Systematic Review and
Meta-Analysis |
title_sort | safety and efficacy of carbon nanoparticle-labeled lymph node
dissection in radical resection of gastric cancer: a systematic review and
meta-analysis |
topic | Screening, Diagnosis, and Treatment of Gastric Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947691/ https://www.ncbi.nlm.nih.gov/pubmed/36877933 http://dx.doi.org/10.1177/15330338231154094 |
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