PTCL, NOS: An update on classification, risk-stratification, and treatment

The peripheral T-cell lymphomas (PTCL) are relatively rare, heterogeneous, and therapeutically challenging. While significant therapeutic gains and improved understanding of disease pathogenesis have been realized for selected PTCL subtypes, the most common PTCL in North America remains “not otherwi...

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Detalles Bibliográficos
Autores principales: Weiss, Jonathan, Reneau, John, Wilcox, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947853/
https://www.ncbi.nlm.nih.gov/pubmed/36845711
http://dx.doi.org/10.3389/fonc.2023.1101441
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author Weiss, Jonathan
Reneau, John
Wilcox, Ryan A.
author_facet Weiss, Jonathan
Reneau, John
Wilcox, Ryan A.
author_sort Weiss, Jonathan
collection PubMed
description The peripheral T-cell lymphomas (PTCL) are relatively rare, heterogeneous, and therapeutically challenging. While significant therapeutic gains and improved understanding of disease pathogenesis have been realized for selected PTCL subtypes, the most common PTCL in North America remains “not otherwise specified (NOS)” and is an unmet need. However, improved understanding of the genetic landscape and ontogeny for the PTCL subtypes currently classified as PTCL, NOS have been realized, and have significant therapeutic implications, which will be reviewed here.
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spelling pubmed-99478532023-02-24 PTCL, NOS: An update on classification, risk-stratification, and treatment Weiss, Jonathan Reneau, John Wilcox, Ryan A. Front Oncol Oncology The peripheral T-cell lymphomas (PTCL) are relatively rare, heterogeneous, and therapeutically challenging. While significant therapeutic gains and improved understanding of disease pathogenesis have been realized for selected PTCL subtypes, the most common PTCL in North America remains “not otherwise specified (NOS)” and is an unmet need. However, improved understanding of the genetic landscape and ontogeny for the PTCL subtypes currently classified as PTCL, NOS have been realized, and have significant therapeutic implications, which will be reviewed here. Frontiers Media S.A. 2023-02-09 /pmc/articles/PMC9947853/ /pubmed/36845711 http://dx.doi.org/10.3389/fonc.2023.1101441 Text en Copyright © 2023 Weiss, Reneau and Wilcox https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Weiss, Jonathan
Reneau, John
Wilcox, Ryan A.
PTCL, NOS: An update on classification, risk-stratification, and treatment
title PTCL, NOS: An update on classification, risk-stratification, and treatment
title_full PTCL, NOS: An update on classification, risk-stratification, and treatment
title_fullStr PTCL, NOS: An update on classification, risk-stratification, and treatment
title_full_unstemmed PTCL, NOS: An update on classification, risk-stratification, and treatment
title_short PTCL, NOS: An update on classification, risk-stratification, and treatment
title_sort ptcl, nos: an update on classification, risk-stratification, and treatment
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947853/
https://www.ncbi.nlm.nih.gov/pubmed/36845711
http://dx.doi.org/10.3389/fonc.2023.1101441
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