Identification of consensus hairpin loop structure among the negative sense subgenomic RNAs of SARS-CoV-2

BACKGROUND: SARS-CoV-2 is the causative agent of worldwide pandemic disease coronavirus disease 19. SARS-CoV-2 bears positive sense RNA genome that has organized and complex pattern of replication/transcription process including the generation of subgenomic RNAs. Transcription regulatory sequences h...

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Autores principales: Bokolia, Naveen Prakash, Gadepalli, Ravisekhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947893/
https://www.ncbi.nlm.nih.gov/pubmed/36852284
http://dx.doi.org/10.1186/s42269-023-01002-3
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author Bokolia, Naveen Prakash
Gadepalli, Ravisekhar
author_facet Bokolia, Naveen Prakash
Gadepalli, Ravisekhar
author_sort Bokolia, Naveen Prakash
collection PubMed
description BACKGROUND: SARS-CoV-2 is the causative agent of worldwide pandemic disease coronavirus disease 19. SARS-CoV-2 bears positive sense RNA genome that has organized and complex pattern of replication/transcription process including the generation of subgenomic RNAs. Transcription regulatory sequences have important role in the pausing of replication/transcription and generation of subgenomic RNAs. RESULTS: In the present bioinformatics analysis, a consensus secondary structure was identified among negative sense subgenomic RNAs of SARS-CoV-2. This consensus region is present at the adjacent of initiation codon. CONCLUSIONS: This study proposed that consensus structured domain could involve in mediating the long pausing of replication/transcription complex and responsible for subgenomic RNA production. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s42269-023-01002-3.
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spelling pubmed-99478932023-02-23 Identification of consensus hairpin loop structure among the negative sense subgenomic RNAs of SARS-CoV-2 Bokolia, Naveen Prakash Gadepalli, Ravisekhar Bull Natl Res Cent Research BACKGROUND: SARS-CoV-2 is the causative agent of worldwide pandemic disease coronavirus disease 19. SARS-CoV-2 bears positive sense RNA genome that has organized and complex pattern of replication/transcription process including the generation of subgenomic RNAs. Transcription regulatory sequences have important role in the pausing of replication/transcription and generation of subgenomic RNAs. RESULTS: In the present bioinformatics analysis, a consensus secondary structure was identified among negative sense subgenomic RNAs of SARS-CoV-2. This consensus region is present at the adjacent of initiation codon. CONCLUSIONS: This study proposed that consensus structured domain could involve in mediating the long pausing of replication/transcription complex and responsible for subgenomic RNA production. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s42269-023-01002-3. Springer Berlin Heidelberg 2023-02-23 2023 /pmc/articles/PMC9947893/ /pubmed/36852284 http://dx.doi.org/10.1186/s42269-023-01002-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Bokolia, Naveen Prakash
Gadepalli, Ravisekhar
Identification of consensus hairpin loop structure among the negative sense subgenomic RNAs of SARS-CoV-2
title Identification of consensus hairpin loop structure among the negative sense subgenomic RNAs of SARS-CoV-2
title_full Identification of consensus hairpin loop structure among the negative sense subgenomic RNAs of SARS-CoV-2
title_fullStr Identification of consensus hairpin loop structure among the negative sense subgenomic RNAs of SARS-CoV-2
title_full_unstemmed Identification of consensus hairpin loop structure among the negative sense subgenomic RNAs of SARS-CoV-2
title_short Identification of consensus hairpin loop structure among the negative sense subgenomic RNAs of SARS-CoV-2
title_sort identification of consensus hairpin loop structure among the negative sense subgenomic rnas of sars-cov-2
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947893/
https://www.ncbi.nlm.nih.gov/pubmed/36852284
http://dx.doi.org/10.1186/s42269-023-01002-3
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