Development of Isopropyl-Tailed Chalcones as a New Class of Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disorder

[Image: see text] Thirteen isopropyl chalcones (CA1–CA13) were synthesized and evaluated for their inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more effectively than MAO-A. Compound CA4 most potently inhibited MAO-B with an IC(50) value of 0.032 μM, similar to t...

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Detalles Bibliográficos
Autores principales: Kumar, Sunil, Oh, Jong Min, Abdelgawad, Mohamed A., Abourehab, Mohammed A.S., Tengli, Anand Kumar, Singh, Ashutosh Kumar, Ahmad, Iqrar, Patel, Harun, Mathew, Bijo, Kim, Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947953/
https://www.ncbi.nlm.nih.gov/pubmed/36844523
http://dx.doi.org/10.1021/acsomega.2c07694

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