Coupled binding and folding of disordered SPIN N-terminal region in myeloperoxidase inhibition

Gram-positive pathogenic bacteria Staphylococcus express and secret staphylococcal peroxidase inhibitor (SPIN) proteins to help evade neutrophil-mediated immunity by inhibiting the activity of the main oxidative-defense player myeloperoxidase (MPO) enzyme. SPIN contains a structured 3-helix bundle C...

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Detalles Bibliográficos
Autores principales: Zhang, Yumeng, Liu, Xiaorong, Chen, Jianhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948029/
https://www.ncbi.nlm.nih.gov/pubmed/36845554
http://dx.doi.org/10.3389/fmolb.2023.1130189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948029/
https://www.ncbi.nlm.nih.gov/pubmed/36845554
http://dx.doi.org/10.3389/fmolb.2023.1130189

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