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Coupled binding and folding of disordered SPIN N-terminal region in myeloperoxidase inhibition

Gram-positive pathogenic bacteria Staphylococcus express and secret staphylococcal peroxidase inhibitor (SPIN) proteins to help evade neutrophil-mediated immunity by inhibiting the activity of the main oxidative-defense player myeloperoxidase (MPO) enzyme. SPIN contains a structured 3-helix bundle C...

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Detalles Bibliográficos
Autores principales:	Zhang, Yumeng, Liu, Xiaorong, Chen, Jianhan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948029/ https://www.ncbi.nlm.nih.gov/pubmed/36845554 http://dx.doi.org/10.3389/fmolb.2023.1130189

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