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A composite score based on immune-related gene prognostic index and m(6)A risk score of head and neck squamous cell carcinoma

Background: Immunotherapy has been demonstrated favorable in head and neck squamous cell carcinoma (HNSCC). Studies indicated that immune-related gene prognostic index (IRGPI) was a robust signature, and N(6)-methyladenosine (m(6)A) methylation had a significant impact on the tumor immune microenvir...

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Autores principales: Yang, Yizhou, Cai, Zeman, Huang, Kaichun, Li, Mei, Wang, Xiao, Lin, Yinbing, Chen, Sijie, Yang, Zhining, Lin, Zhixiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948032/
https://www.ncbi.nlm.nih.gov/pubmed/36845378
http://dx.doi.org/10.3389/fgene.2023.1061569
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author Yang, Yizhou
Cai, Zeman
Huang, Kaichun
Li, Mei
Wang, Xiao
Lin, Yinbing
Chen, Sijie
Yang, Zhining
Lin, Zhixiong
author_facet Yang, Yizhou
Cai, Zeman
Huang, Kaichun
Li, Mei
Wang, Xiao
Lin, Yinbing
Chen, Sijie
Yang, Zhining
Lin, Zhixiong
author_sort Yang, Yizhou
collection PubMed
description Background: Immunotherapy has been demonstrated favorable in head and neck squamous cell carcinoma (HNSCC). Studies indicated that immune-related gene prognostic index (IRGPI) was a robust signature, and N(6)-methyladenosine (m(6)A) methylation had a significant impact on the tumor immune microenvironment (TIME) and immunotherapy of head and neck squamous cell carcinoma. Thus, combining indicated that immune-related gene prognostic index with m(6)A status should offer a better predictive power for immune responses. Methods: Head and neck squamous cell carcinoma samples from the cancer genome atlas (TCGA, n = 498) and gene expression omnibus database (GSE65858, n = 270) were used in this study. Cox regression analysis was used to construct the indicated that immune-related gene prognostic index through immune-related hub genes which were identified by weighted gene co-expression network analysis (WGCNA). The m(6)A risk score was constructed by least absolute shrinkage and selection operator (LASSO) regression analysis. Principal component analysis was used to construct a composite score, and systematically correlate subgroups according to tumor immune microenvironment cell-infiltrating characteristics. Results: A composite score was determined based on indicated that immune-related gene prognostic index and m(6)A risk score. Head and neck squamous cell carcinoma patients in the cancer genome atlas were divided into four subgroups: A (IRGPI-High&m(6)A-risk-High, n = 127), B (IRGPI-High&m(6)A-risk-Low, n = 99), C (IRGPI-Low&m(6)A-risk-High, n = 99), and D (IRGPI-Low&m(6)A-risk-Low, n = 128), and overall survival (OS) was significantly different between subgroups (p < 0.001). The characteristics of tumor immune microenvironment cell infiltration in the four subgroups were significantly different in subgroups (p < 0.05). The receiver operating characteristic (ROC) curves show the predictive value of composite score for overall survival was superior to other scores. Conclusion: The composite score is a promising prognostic signature which might distinguish immune and molecular characteristics, predict prognosis, and guide more effective immunotherapeutic strategies for head and neck squamous cell carcinoma.
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spelling pubmed-99480322023-02-24 A composite score based on immune-related gene prognostic index and m(6)A risk score of head and neck squamous cell carcinoma Yang, Yizhou Cai, Zeman Huang, Kaichun Li, Mei Wang, Xiao Lin, Yinbing Chen, Sijie Yang, Zhining Lin, Zhixiong Front Genet Genetics Background: Immunotherapy has been demonstrated favorable in head and neck squamous cell carcinoma (HNSCC). Studies indicated that immune-related gene prognostic index (IRGPI) was a robust signature, and N(6)-methyladenosine (m(6)A) methylation had a significant impact on the tumor immune microenvironment (TIME) and immunotherapy of head and neck squamous cell carcinoma. Thus, combining indicated that immune-related gene prognostic index with m(6)A status should offer a better predictive power for immune responses. Methods: Head and neck squamous cell carcinoma samples from the cancer genome atlas (TCGA, n = 498) and gene expression omnibus database (GSE65858, n = 270) were used in this study. Cox regression analysis was used to construct the indicated that immune-related gene prognostic index through immune-related hub genes which were identified by weighted gene co-expression network analysis (WGCNA). The m(6)A risk score was constructed by least absolute shrinkage and selection operator (LASSO) regression analysis. Principal component analysis was used to construct a composite score, and systematically correlate subgroups according to tumor immune microenvironment cell-infiltrating characteristics. Results: A composite score was determined based on indicated that immune-related gene prognostic index and m(6)A risk score. Head and neck squamous cell carcinoma patients in the cancer genome atlas were divided into four subgroups: A (IRGPI-High&m(6)A-risk-High, n = 127), B (IRGPI-High&m(6)A-risk-Low, n = 99), C (IRGPI-Low&m(6)A-risk-High, n = 99), and D (IRGPI-Low&m(6)A-risk-Low, n = 128), and overall survival (OS) was significantly different between subgroups (p < 0.001). The characteristics of tumor immune microenvironment cell infiltration in the four subgroups were significantly different in subgroups (p < 0.05). The receiver operating characteristic (ROC) curves show the predictive value of composite score for overall survival was superior to other scores. Conclusion: The composite score is a promising prognostic signature which might distinguish immune and molecular characteristics, predict prognosis, and guide more effective immunotherapeutic strategies for head and neck squamous cell carcinoma. Frontiers Media S.A. 2023-02-09 /pmc/articles/PMC9948032/ /pubmed/36845378 http://dx.doi.org/10.3389/fgene.2023.1061569 Text en Copyright © 2023 Yang, Cai, Huang, Li, Wang, Lin, Chen, Yang and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Yang, Yizhou
Cai, Zeman
Huang, Kaichun
Li, Mei
Wang, Xiao
Lin, Yinbing
Chen, Sijie
Yang, Zhining
Lin, Zhixiong
A composite score based on immune-related gene prognostic index and m(6)A risk score of head and neck squamous cell carcinoma
title A composite score based on immune-related gene prognostic index and m(6)A risk score of head and neck squamous cell carcinoma
title_full A composite score based on immune-related gene prognostic index and m(6)A risk score of head and neck squamous cell carcinoma
title_fullStr A composite score based on immune-related gene prognostic index and m(6)A risk score of head and neck squamous cell carcinoma
title_full_unstemmed A composite score based on immune-related gene prognostic index and m(6)A risk score of head and neck squamous cell carcinoma
title_short A composite score based on immune-related gene prognostic index and m(6)A risk score of head and neck squamous cell carcinoma
title_sort composite score based on immune-related gene prognostic index and m(6)a risk score of head and neck squamous cell carcinoma
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948032/
https://www.ncbi.nlm.nih.gov/pubmed/36845378
http://dx.doi.org/10.3389/fgene.2023.1061569
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