Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling

Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic events that lead to disease and the degree to which they are common across MAPT mutations remain poorly understood. The goal...

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Detalles Bibliográficos
Autores principales: Minaya, Miguel A., Mahali, Sidhartha, Iyer, Abhirami K., Eteleeb, Abdallah M., Martinez, Rita, Huang, Guangming, Budde, John, Temple, Sally, Nana, Alissa L., Seeley, William W., Spina, Salvatore, Grinberg, Lea T., Harari, Oscar, Karch, Celeste M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948093/
https://www.ncbi.nlm.nih.gov/pubmed/36845551
http://dx.doi.org/10.3389/fmolb.2023.1051494

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