Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis

[Image: see text] Efficient O-alkylation of phenols and carboxylic acids has essential applications in organic synthesis. A mild alkylation method for phenolic and carboxylic OH groups is developed using alkyl halides as alkylation reagents and tetrabutylammonium hydroxide as a base, and lignin mono...

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Detalles Bibliográficos
Autores principales: Zuo, Yajie, Zhu, Siying, Liu, Yi, Zhao, Jingjing, Zhang, Shiyi, Zhong, Chongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948209/
https://www.ncbi.nlm.nih.gov/pubmed/36844551
http://dx.doi.org/10.1021/acsomega.2c07920
Descripción
Sumario:[Image: see text] Efficient O-alkylation of phenols and carboxylic acids has essential applications in organic synthesis. A mild alkylation method for phenolic and carboxylic OH groups is developed using alkyl halides as alkylation reagents and tetrabutylammonium hydroxide as a base, and lignin monomers can be fully methylated in quantitative yields. Additionally, phenolic and carboxylic OH groups can be alkylated by different alkyl halides in one pot in different solvent systems.

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