Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis

[Image: see text] Efficient O-alkylation of phenols and carboxylic acids has essential applications in organic synthesis. A mild alkylation method for phenolic and carboxylic OH groups is developed using alkyl halides as alkylation reagents and tetrabutylammonium hydroxide as a base, and lignin mono...

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Autores principales: Zuo, Yajie, Zhu, Siying, Liu, Yi, Zhao, Jingjing, Zhang, Shiyi, Zhong, Chongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948209/
https://www.ncbi.nlm.nih.gov/pubmed/36844551
http://dx.doi.org/10.1021/acsomega.2c07920
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author Zuo, Yajie
Zhu, Siying
Liu, Yi
Zhao, Jingjing
Zhang, Shiyi
Zhong, Chongmin
author_facet Zuo, Yajie
Zhu, Siying
Liu, Yi
Zhao, Jingjing
Zhang, Shiyi
Zhong, Chongmin
author_sort Zuo, Yajie
collection PubMed
description [Image: see text] Efficient O-alkylation of phenols and carboxylic acids has essential applications in organic synthesis. A mild alkylation method for phenolic and carboxylic OH groups is developed using alkyl halides as alkylation reagents and tetrabutylammonium hydroxide as a base, and lignin monomers can be fully methylated in quantitative yields. Additionally, phenolic and carboxylic OH groups can be alkylated by different alkyl halides in one pot in different solvent systems.
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spelling pubmed-99482092023-02-24 Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis Zuo, Yajie Zhu, Siying Liu, Yi Zhao, Jingjing Zhang, Shiyi Zhong, Chongmin ACS Omega [Image: see text] Efficient O-alkylation of phenols and carboxylic acids has essential applications in organic synthesis. A mild alkylation method for phenolic and carboxylic OH groups is developed using alkyl halides as alkylation reagents and tetrabutylammonium hydroxide as a base, and lignin monomers can be fully methylated in quantitative yields. Additionally, phenolic and carboxylic OH groups can be alkylated by different alkyl halides in one pot in different solvent systems. American Chemical Society 2023-02-10 /pmc/articles/PMC9948209/ /pubmed/36844551 http://dx.doi.org/10.1021/acsomega.2c07920 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Zuo, Yajie
Zhu, Siying
Liu, Yi
Zhao, Jingjing
Zhang, Shiyi
Zhong, Chongmin
Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis
title Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis
title_full Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis
title_fullStr Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis
title_full_unstemmed Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis
title_short Quantitative Methylation of Lignin Monomers Using Tetrabutylammonium Hydroxide and MeI and Applications in Organic Synthesis
title_sort quantitative methylation of lignin monomers using tetrabutylammonium hydroxide and mei and applications in organic synthesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948209/
https://www.ncbi.nlm.nih.gov/pubmed/36844551
http://dx.doi.org/10.1021/acsomega.2c07920
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