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Practical Prediction Model for Ovarian Insufficiency after Radiation

Objective  The present study aimed to develop a useful mathematical model that predicts the age at which premature ovarian insufficiency might occur after teletherapy radiation. A diagnosis of premature or early menopause has physical and psychological consequences, so women may need support and lon...

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Detalles Bibliográficos
Autores principales: Gil, Gabriel Oliveira Bernardes, Asano, Cassiano, Andrade, Warne Pedro de, Gil, Maria Luísa Braga Vieira, Cândido, Eduardo Batista, Regalin, Marcos, Queiroz, Izabella Nobre, Cantídio, Farley Soares, Delfino, Darly Gomes Soares, Silva-Filho, Agnaldo Lopes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948280/
https://www.ncbi.nlm.nih.gov/pubmed/35617949
http://dx.doi.org/10.1055/s-0042-1746199
Descripción
Sumario:Objective  The present study aimed to develop a useful mathematical model that predicts the age at which premature ovarian insufficiency might occur after teletherapy radiation. A diagnosis of premature or early menopause has physical and psychological consequences, so women may need support and long-term medical follow-up. Methods  To correlate ovarian radiation dose with ovarian function, we used the formula described by Wallace et al.: √g(z) = 10 ((2-0,15z)) , where “g(z)” and “z” represent oocyte survival rate and the radiation dose (in Gray), respectively. By simulating different ages and doses, we observed a pattern that could be used to simplify the relationship between radiation dose and remaining time of ovarian function. Results  We obtained a linear function between ovarian radiation dose and loss of ovarian function (LOF) that is the percentage of decrease in the time to the ovarian failure compared with the time expected for a woman at the same age without irradiation exposition. For patients < 40 years old and with ovarian radiation doses < 5 Gy, the equation LOF = 2.70 + (11.08 x Dose) can be applied to estimate the decrease in time to premature ovarian insufficiency. Conclusion  The present study reports a practicable theoretical method to estimate the loss of ovarian function. These findings can potentially improve the management and counseling of young women patients submitted to radiotherapy during their reproductive years.