Epigenetic markers in the embryonal germ cell development and spermatogenesis

Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis. During spermatogenesis, key spermatogenic events such as stem cell self-renewal and commitment to meiosis, meiotic recombination, meiotic sex chromosom...

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Autores principales: Odroniec, Amadeusz, Olszewska, Marta, Kurpisz, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948345/
https://www.ncbi.nlm.nih.gov/pubmed/36814207
http://dx.doi.org/10.1186/s12610-022-00179-3
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author Odroniec, Amadeusz
Olszewska, Marta
Kurpisz, Maciej
author_facet Odroniec, Amadeusz
Olszewska, Marta
Kurpisz, Maciej
author_sort Odroniec, Amadeusz
collection PubMed
description Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis. During spermatogenesis, key spermatogenic events such as stem cell self-renewal and commitment to meiosis, meiotic recombination, meiotic sex chromosome inactivation, followed by cellular and chromatin remodeling of elongating spermatids occur, leading to sperm cell production. All the mentioned events are at least partially controlled by the epigenetic modifications of DNA and histones. Additionally, during embryonal development in primordial germ cells, global epigenetic reprogramming of DNA occurs. In this review, we summarized the most important epigenetic modifications in the particular stages of germ cell development, in DNA and histone proteins, starting from primordial germ cells, during embryonal development, and ending with histone-to-protamine transition during spermiogenesis.
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spelling pubmed-99483452023-02-24 Epigenetic markers in the embryonal germ cell development and spermatogenesis Odroniec, Amadeusz Olszewska, Marta Kurpisz, Maciej Basic Clin Androl Review Article Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis. During spermatogenesis, key spermatogenic events such as stem cell self-renewal and commitment to meiosis, meiotic recombination, meiotic sex chromosome inactivation, followed by cellular and chromatin remodeling of elongating spermatids occur, leading to sperm cell production. All the mentioned events are at least partially controlled by the epigenetic modifications of DNA and histones. Additionally, during embryonal development in primordial germ cells, global epigenetic reprogramming of DNA occurs. In this review, we summarized the most important epigenetic modifications in the particular stages of germ cell development, in DNA and histone proteins, starting from primordial germ cells, during embryonal development, and ending with histone-to-protamine transition during spermiogenesis. BioMed Central 2023-02-23 /pmc/articles/PMC9948345/ /pubmed/36814207 http://dx.doi.org/10.1186/s12610-022-00179-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review Article
Odroniec, Amadeusz
Olszewska, Marta
Kurpisz, Maciej
Epigenetic markers in the embryonal germ cell development and spermatogenesis
title Epigenetic markers in the embryonal germ cell development and spermatogenesis
title_full Epigenetic markers in the embryonal germ cell development and spermatogenesis
title_fullStr Epigenetic markers in the embryonal germ cell development and spermatogenesis
title_full_unstemmed Epigenetic markers in the embryonal germ cell development and spermatogenesis
title_short Epigenetic markers in the embryonal germ cell development and spermatogenesis
title_sort epigenetic markers in the embryonal germ cell development and spermatogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948345/
https://www.ncbi.nlm.nih.gov/pubmed/36814207
http://dx.doi.org/10.1186/s12610-022-00179-3
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