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Individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer

OBJECTIVES: The purpose of this study was to explore the influence of individual patient factors, such as volume of the planning target volume (PTV) (V(PTV)), cardiothoracic ratio (CTR), central lung distance (CLD), and maximal heart distance (MHD), on the design of treatment plans in terms of targe...

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Autores principales: Wang, Yong, Ni, Lingqin, Ying, Shenpeng, Xu, Yuanyuan, Chen, Weijun, Liu, Yanmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948370/
https://www.ncbi.nlm.nih.gov/pubmed/36823541
http://dx.doi.org/10.1186/s12957-023-02936-8
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author Wang, Yong
Ni, Lingqin
Ying, Shenpeng
Xu, Yuanyuan
Chen, Weijun
Liu, Yanmei
author_facet Wang, Yong
Ni, Lingqin
Ying, Shenpeng
Xu, Yuanyuan
Chen, Weijun
Liu, Yanmei
author_sort Wang, Yong
collection PubMed
description OBJECTIVES: The purpose of this study was to explore the influence of individual patient factors, such as volume of the planning target volume (PTV) (V(PTV)), cardiothoracic ratio (CTR), central lung distance (CLD), and maximal heart distance (MHD), on the design of treatment plans in terms of target dose coverage, integral dose, and dose to organs at risk (OAR) in early breast cancer. METHODS: Ninety-six patients were selected for this study. Radiation doses of 50 Gy and a simultaneous dose of 60 Gy in 25 fractions were administered to the whole breast and tumor bed, respectively. The intensity modulation plan (IMRT) of each patient uses both physical parameters and an equivalent uniform dose (EUD) to optimize the target function. Univariate and multivariate linear regression were used to analyze the relationship between predictive impact factors and OAR percent dose volume, conformity index (CI), and homogeneity index (HI). RESULTS: The average CI and HI values of the left breast cancer plan were 0.595 ± 0.071 (0.3–0.72) and 1.095 ± 0.023 (1.06–1.18), respectively. The CTR (B = 0.21, P = 0.045), V(PTV) (B = 0.63, P = 0.000), volume of the lung (V(lung)) (B =  − 0.29, P = 0.005), and MHD (B = 0.22, P = 0.041) were identified as factors influencing the CI index of the left breast cancer intensity modulation plan. V(PTV) (B = 1.087, P = 0.022) was identified as the influencing factor of the HI index of the left breast cancer intensity modulation plan. volume of the heart (V(heart)) (B =  − 0.43, P = 0.001) and CLD (B = 0.28, P = 0.008) were influencing factors of the volume of lung (V(lung20)) of the lung. The prediction formulas for left-sided breast cancer are noted as follows: CI = 0.459 + 0.19CTR-0.16CLD, V(lung)10 = 35.5–0.02V(heart); and V(lung)20 = 21.48 + 2.8CLD-0.018V(heart). CONCLUSIONS: CTR, CLD, and MHD can predict the rationality of the parameters of the left breast cancer IMRT. The calculation formula generated based on this information can help the physicist choose the optimal radiation field setting method and improve the quality of the treatment plan.
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spelling pubmed-99483702023-02-24 Individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer Wang, Yong Ni, Lingqin Ying, Shenpeng Xu, Yuanyuan Chen, Weijun Liu, Yanmei World J Surg Oncol Research OBJECTIVES: The purpose of this study was to explore the influence of individual patient factors, such as volume of the planning target volume (PTV) (V(PTV)), cardiothoracic ratio (CTR), central lung distance (CLD), and maximal heart distance (MHD), on the design of treatment plans in terms of target dose coverage, integral dose, and dose to organs at risk (OAR) in early breast cancer. METHODS: Ninety-six patients were selected for this study. Radiation doses of 50 Gy and a simultaneous dose of 60 Gy in 25 fractions were administered to the whole breast and tumor bed, respectively. The intensity modulation plan (IMRT) of each patient uses both physical parameters and an equivalent uniform dose (EUD) to optimize the target function. Univariate and multivariate linear regression were used to analyze the relationship between predictive impact factors and OAR percent dose volume, conformity index (CI), and homogeneity index (HI). RESULTS: The average CI and HI values of the left breast cancer plan were 0.595 ± 0.071 (0.3–0.72) and 1.095 ± 0.023 (1.06–1.18), respectively. The CTR (B = 0.21, P = 0.045), V(PTV) (B = 0.63, P = 0.000), volume of the lung (V(lung)) (B =  − 0.29, P = 0.005), and MHD (B = 0.22, P = 0.041) were identified as factors influencing the CI index of the left breast cancer intensity modulation plan. V(PTV) (B = 1.087, P = 0.022) was identified as the influencing factor of the HI index of the left breast cancer intensity modulation plan. volume of the heart (V(heart)) (B =  − 0.43, P = 0.001) and CLD (B = 0.28, P = 0.008) were influencing factors of the volume of lung (V(lung20)) of the lung. The prediction formulas for left-sided breast cancer are noted as follows: CI = 0.459 + 0.19CTR-0.16CLD, V(lung)10 = 35.5–0.02V(heart); and V(lung)20 = 21.48 + 2.8CLD-0.018V(heart). CONCLUSIONS: CTR, CLD, and MHD can predict the rationality of the parameters of the left breast cancer IMRT. The calculation formula generated based on this information can help the physicist choose the optimal radiation field setting method and improve the quality of the treatment plan. BioMed Central 2023-02-23 /pmc/articles/PMC9948370/ /pubmed/36823541 http://dx.doi.org/10.1186/s12957-023-02936-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Yong
Ni, Lingqin
Ying, Shenpeng
Xu, Yuanyuan
Chen, Weijun
Liu, Yanmei
Individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer
title Individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer
title_full Individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer
title_fullStr Individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer
title_full_unstemmed Individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer
title_short Individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer
title_sort individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948370/
https://www.ncbi.nlm.nih.gov/pubmed/36823541
http://dx.doi.org/10.1186/s12957-023-02936-8
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