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Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence, PANoptosis is a highly coordinated and dynamically balanced programmed inflammatory cell death pathway that combines the main f...

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Autores principales: Zhu, Peng, Ke, Zhuo-Ran, Chen, Jing-Xian, Li, Shi-Jin, Ma, Tian-Liang, Fan, Xiao-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948402/
https://www.ncbi.nlm.nih.gov/pubmed/36845112
http://dx.doi.org/10.3389/fimmu.2023.1120034
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author Zhu, Peng
Ke, Zhuo-Ran
Chen, Jing-Xian
Li, Shi-Jin
Ma, Tian-Liang
Fan, Xiao-Lei
author_facet Zhu, Peng
Ke, Zhuo-Ran
Chen, Jing-Xian
Li, Shi-Jin
Ma, Tian-Liang
Fan, Xiao-Lei
author_sort Zhu, Peng
collection PubMed
description PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence, PANoptosis is a highly coordinated and dynamically balanced programmed inflammatory cell death pathway that combines the main features of pyroptosis, apoptosis, and necroptosis. Many variables, such as infection, injury, or self-defect, may be involved in the occurrence of PANoptosis, with the assembly and activation of the PANoptosome being the most critical. PANoptosis has been linked to the development of multiple systemic diseases in the human body, including infectious diseases, cancer, neurodegenerative diseases, and inflammatory diseases. Therefore, it is necessary to clarify the process of occurrence, the regulatory mechanism of PANoptosis, and its relation to diseases. In this paper, we summarized the differences and relations between PANoptosis and the three types of programmed cell death, and emphatically expounded molecular mechanism and regulatory patterns of PANoptosis, with the expectation of facilitating the application of PANoptosis regulation in disease treatment.
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spelling pubmed-99484022023-02-24 Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment Zhu, Peng Ke, Zhuo-Ran Chen, Jing-Xian Li, Shi-Jin Ma, Tian-Liang Fan, Xiao-Lei Front Immunol Immunology PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence, PANoptosis is a highly coordinated and dynamically balanced programmed inflammatory cell death pathway that combines the main features of pyroptosis, apoptosis, and necroptosis. Many variables, such as infection, injury, or self-defect, may be involved in the occurrence of PANoptosis, with the assembly and activation of the PANoptosome being the most critical. PANoptosis has been linked to the development of multiple systemic diseases in the human body, including infectious diseases, cancer, neurodegenerative diseases, and inflammatory diseases. Therefore, it is necessary to clarify the process of occurrence, the regulatory mechanism of PANoptosis, and its relation to diseases. In this paper, we summarized the differences and relations between PANoptosis and the three types of programmed cell death, and emphatically expounded molecular mechanism and regulatory patterns of PANoptosis, with the expectation of facilitating the application of PANoptosis regulation in disease treatment. Frontiers Media S.A. 2023-02-09 /pmc/articles/PMC9948402/ /pubmed/36845112 http://dx.doi.org/10.3389/fimmu.2023.1120034 Text en Copyright © 2023 Zhu, Ke, Chen, Li, Ma and Fan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhu, Peng
Ke, Zhuo-Ran
Chen, Jing-Xian
Li, Shi-Jin
Ma, Tian-Liang
Fan, Xiao-Lei
Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment
title Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment
title_full Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment
title_fullStr Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment
title_full_unstemmed Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment
title_short Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment
title_sort advances in mechanism and regulation of panoptosis: prospects in disease treatment
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948402/
https://www.ncbi.nlm.nih.gov/pubmed/36845112
http://dx.doi.org/10.3389/fimmu.2023.1120034
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