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Implementation of targeted cholera response activities, Cameroon
OBJECTIVE: To describe the implementation of case-area targeted interventions to reduce cholera transmission using a rapid, localized response in Kribi district, Cameroon. METHODS: We used a cross-sectional design to study the implementation of case-area targeted interventions. We initiated interven...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
World Health Organization
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948504/ https://www.ncbi.nlm.nih.gov/pubmed/36865607 http://dx.doi.org/10.2471/BLT.22.288885 |
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author | Ouamba, Jean Patrick Mbarga, Nicole Fouda Ciglenecki, Iza Ratnayake, Ruwan Tchiasso, Dora Finger, Flavio Peyraud, Nicolas Mounchili, Iscander Boyom, Thierry Yonta, Cyrille Nwatchok, Liliane Mouhamadou, Moustapha Ekedi, Christine Marcel, Johne Luquero, Francisco Ekah, Faustin Amani, Adidja Tamakloe, Modeste Boum, Yap Esso, Linda |
author_facet | Ouamba, Jean Patrick Mbarga, Nicole Fouda Ciglenecki, Iza Ratnayake, Ruwan Tchiasso, Dora Finger, Flavio Peyraud, Nicolas Mounchili, Iscander Boyom, Thierry Yonta, Cyrille Nwatchok, Liliane Mouhamadou, Moustapha Ekedi, Christine Marcel, Johne Luquero, Francisco Ekah, Faustin Amani, Adidja Tamakloe, Modeste Boum, Yap Esso, Linda |
author_sort | Ouamba, Jean Patrick |
collection | PubMed |
description | OBJECTIVE: To describe the implementation of case-area targeted interventions to reduce cholera transmission using a rapid, localized response in Kribi district, Cameroon. METHODS: We used a cross-sectional design to study the implementation of case-area targeted interventions. We initiated interventions after rapid diagnostic test confirmation of a case of cholera. We targeted households within a 100–250 metre perimeter around the index case (spatial targeting). The interventions package included: health promotion, oral cholera vaccination, antibiotic chemoprophylaxis for nonimmunized direct contacts, point-of-use water treatment and active case-finding. FINDINGS: We implemented eight targeted intervention packages in four health areas of Kribi between 17 September 2020 and 16 October 2020. We visited 1533 households (range: 7–544 per case-area) hosting 5877 individuals (range: 7–1687 per case-area). The average time from detection of the index case to implementation of interventions was 3.4 days (range: 1–7). Oral cholera vaccination increased overall immunization coverage in Kribi from 49.2% (2771/5621 people) to 79.3% (4456/5621 people). Interventions also led to the detection and prompt management of eight suspected cases of cholera, five of whom had severe dehydration. Stool culture was positive for Vibrio cholerae O1 in four cases. The average time from onset of symptoms to admission of a person with cholera to a health facility was 1.2 days. CONCLUSION: Despite challenges, we successfully implemented targeted interventions at the tail-end of a cholera epidemic, after which no further cases were reported in Kribi up until week 49 of 2021. The effectiveness of case-area targeted interventions in stopping or reducing cholera transmission needs further investigation. |
format | Online Article Text |
id | pubmed-9948504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | World Health Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-99485042023-03-01 Implementation of targeted cholera response activities, Cameroon Ouamba, Jean Patrick Mbarga, Nicole Fouda Ciglenecki, Iza Ratnayake, Ruwan Tchiasso, Dora Finger, Flavio Peyraud, Nicolas Mounchili, Iscander Boyom, Thierry Yonta, Cyrille Nwatchok, Liliane Mouhamadou, Moustapha Ekedi, Christine Marcel, Johne Luquero, Francisco Ekah, Faustin Amani, Adidja Tamakloe, Modeste Boum, Yap Esso, Linda Bull World Health Organ Research OBJECTIVE: To describe the implementation of case-area targeted interventions to reduce cholera transmission using a rapid, localized response in Kribi district, Cameroon. METHODS: We used a cross-sectional design to study the implementation of case-area targeted interventions. We initiated interventions after rapid diagnostic test confirmation of a case of cholera. We targeted households within a 100–250 metre perimeter around the index case (spatial targeting). The interventions package included: health promotion, oral cholera vaccination, antibiotic chemoprophylaxis for nonimmunized direct contacts, point-of-use water treatment and active case-finding. FINDINGS: We implemented eight targeted intervention packages in four health areas of Kribi between 17 September 2020 and 16 October 2020. We visited 1533 households (range: 7–544 per case-area) hosting 5877 individuals (range: 7–1687 per case-area). The average time from detection of the index case to implementation of interventions was 3.4 days (range: 1–7). Oral cholera vaccination increased overall immunization coverage in Kribi from 49.2% (2771/5621 people) to 79.3% (4456/5621 people). Interventions also led to the detection and prompt management of eight suspected cases of cholera, five of whom had severe dehydration. Stool culture was positive for Vibrio cholerae O1 in four cases. The average time from onset of symptoms to admission of a person with cholera to a health facility was 1.2 days. CONCLUSION: Despite challenges, we successfully implemented targeted interventions at the tail-end of a cholera epidemic, after which no further cases were reported in Kribi up until week 49 of 2021. The effectiveness of case-area targeted interventions in stopping or reducing cholera transmission needs further investigation. World Health Organization 2023-03-01 2023-01-18 /pmc/articles/PMC9948504/ /pubmed/36865607 http://dx.doi.org/10.2471/BLT.22.288885 Text en (c) 2023 The authors; licensee World Health Organization. https://creativecommons.org/licenses/by/3.0/igo/This is an open access article distributed under the terms of the Creative Commons Attribution IGO License (http://creativecommons.org/licenses/by/3.0/igo/legalcode (https://creativecommons.org/licenses/by/3.0/igo/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any reproduction of this article there should not be any suggestion that WHO or this article endorse any specific organization or products. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL. |
spellingShingle | Research Ouamba, Jean Patrick Mbarga, Nicole Fouda Ciglenecki, Iza Ratnayake, Ruwan Tchiasso, Dora Finger, Flavio Peyraud, Nicolas Mounchili, Iscander Boyom, Thierry Yonta, Cyrille Nwatchok, Liliane Mouhamadou, Moustapha Ekedi, Christine Marcel, Johne Luquero, Francisco Ekah, Faustin Amani, Adidja Tamakloe, Modeste Boum, Yap Esso, Linda Implementation of targeted cholera response activities, Cameroon |
title | Implementation of targeted cholera response activities, Cameroon |
title_full | Implementation of targeted cholera response activities, Cameroon |
title_fullStr | Implementation of targeted cholera response activities, Cameroon |
title_full_unstemmed | Implementation of targeted cholera response activities, Cameroon |
title_short | Implementation of targeted cholera response activities, Cameroon |
title_sort | implementation of targeted cholera response activities, cameroon |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948504/ https://www.ncbi.nlm.nih.gov/pubmed/36865607 http://dx.doi.org/10.2471/BLT.22.288885 |
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